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KCNJ9 抗体

KCNJ9 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN317838
发货至: 中国
  • 抗原 See all KCNJ9 抗体
    KCNJ9 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 9 (KCNJ9))
    适用
    • 39
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    人, 小鼠, 大鼠
    宿主
    • 39
    克隆类型
    • 39
    多克隆
    标记
    • 12
    • 2
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    • 1
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    This KCNJ9 antibody is un-conjugated
    应用范围
    • 31
    • 13
    • 13
    • 12
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB)
    特异性
    KIR3.3 antibody detects endogenous levels of KIR3.3 protein.(region surrounding Asp94)
    纯化方法
    Affinity chromatography
    Top Product
    Discover our top product KCNJ9 Primary Antibody
  • 应用备注
    ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1,0 mg/mL
    缓冲液
    Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    KCNJ9 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 9 (KCNJ9))
    别名
    KCNJ9 (KCNJ9 产品)
    别名
    GIRK3 antibody, KIR3.3 antibody, 1700085N21Rik antibody, Girk3 antibody, Kir3.3 antibody, mbGIRK3 antibody, potassium voltage-gated channel subfamily J member 9 antibody, potassium inwardly-rectifying channel, subfamily J, member 9 antibody, KCNJ9 antibody, Kcnj9 antibody
    背景
    G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbγ subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbγ dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbγ dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.Synonyms: G protein-activated inward rectifier potassium channel 3, GIRK3, Inwardly rectifier K(+) channel Kir3.3, KCNJ9, Potassium channel, inwardly rectifying subfamily J member 9
    分子量
    approx. 44 kDa
    基因ID
    3765
    NCBI登录号
    NP_004974
    UniProt
    Q92806
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