KDELR3 抗体
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北京 101111
Quick Overview for KDELR3 抗体 (ABIN317836)
抗原
See all KDELR3 (kDELR3) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- KDEL Receptor 3 antibody detects endogenous levels of KDEL Receptor 3 protein.(region surrounding Leu95)
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纯化方法
- Affinity chromatography
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应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- KDELR3 (kDELR3) (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 3 (kDELR3))
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别名
- KDEL Receptor 3 / KDELR3
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背景
- Soluble proteins in the endoplasmic reticulum (ER) contain a specific carboxy terminal sequence KDEL (Lys-Asp-Glu-Leu), and include the coat proteins required for vesicle budding from the ER, proteins that form retrogradevesicles on post-ER compartments, and integral membrane proteins that target vesicles to their correct destination. The retention of these soluble proteins in the ER depends on the interaction of the KDEL sequence with the corresponding KDEL receptor, also designated ERD2, in the Golgi apparatus.When KDEL proteins reach the Golgi complex, they are recognized by the KDEL receptor and transported retrograde in COPI-coated vesicles back to the ER. The small GTPase ADP-ribosylation factor 1 (ARF1), a regulator of vesicle transport, interacts with the KDEL receptor.Synonyms: ER lumen protein retaining receptor 3, KDEL endoplasmic reticulum protein retention receptor 3
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分子量
- approx. 28 kDa
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基因ID
- 11015
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NCBI登录号
- NP_006846
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UniProt
- O43731
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途径
- ER-Nucleus Signaling, Maintenance of Protein Location
抗原
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