AKR1B1 抗体
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北京 101111
Quick Overview for AKR1B1 抗体 (ABIN317815)
抗原
See all AKR1B1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Aldose Reductase antibody detects endogenous levels of Aldose Reductase protein.(region surrounding Lys275)
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纯化方法
- Affinity chromatography
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anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 1-316) antibody
AKR1B1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) antibodyAKR1B1 适用: 人 WB, IHC, IF 宿主: 小鼠 Monoclonal CPTC-AKR1B1-3 unconjugated
anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 102-135) antibodyAKR1B1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB14877 unconjugated
anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 228-316) antibodyAKR1B1 适用: 人, 大鼠, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 1-316) antibodyAKR1B1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2D12 unconjugated
anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) antibodyKD Validated AKR1B1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB6775 unconjugated
anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 290-316), (C-Term) antibodyAKR1B1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB14692 unconjugated
anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 1-316) antibodyAKR1B1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 114-230) antibodyAKR1B1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1) (AA 287-316), (C-Term) antibodyAKR1B1 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/20000 - 1/40000. Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- AKR1B1 (Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))
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别名
- AKR1B1 / ALDR1
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背景
- Aldose reductase (also designated AKR1B1, ALDR1, ALR2 or AR) is member of the monomeric NADPH-dependent aldoketoreductase family. Aldose reductase, which has a molecular mass of 36 kDa, catalyzes the reduction of various aldehydes and has been implicated in the development of diabetic complications by catalyzing the reduction of the aldehyde form of glucose, to the corresponding sugar alcohol, sorbitol. This pathway plays a minor role in glucose metabolism in most tissues, however in diabetic hyperglycemia, cells undergoing insulin-independent uptake of glucose accumulate significant quantities of sorbitol. The resulting hyperosmotic stress to cells may be a cause of diabetic complications such as neuropathy, retinopathy, and cataracts. Aldose reductase is very similar to human aldehyde reductase, bovine prostaglandin F synthase and to the European common frog protein, rho-crystallin.Synonyms: Aldose reductase
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分子量
- approx. 36 kDa
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基因ID
- 231
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NCBI登录号
- NP_001619
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UniProt
- P15121
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途径
- Metabolism of Steroid Hormones and Vitamin D, C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process
抗原
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