Melatonin Receptor 1B 抗体
Quick Overview for Melatonin Receptor 1B 抗体 (ABIN317757)
抗原
See all Melatonin Receptor 1B (MTNR1B) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of MEL-1B-R protein.
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纯化方法
- Affinity Chromatography using epitope-specific immunogen
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应用备注
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ELISA: 1/1000approx. 1/5000. Western blot: 1/500approx. 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Melatonin Receptor 1B (MTNR1B)
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别名
- Melatonin Receptor 1B
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背景
- The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the superfamily of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. The melatonin receptors are activated by the hormone melatonin (Mel), which is secreted by the pineal gland at night as part of the circadian clock. MEL-1A-R, a 37 kD protein, is thought to be involved in pacing the biological clock. However, both MEL-1A-R and MEL-1B-R are implicated in controlling cellular growth in response to melatonin. MEL-1B-R is an integral membrane protein expressed in retina and less in brain and hippocampus. Functional studies of NIH/3T3 cells stably expressing the MEL-1B-R melatonin receptor indicate that it is coupled to inhibition of adenylyl cyclase.Synonyms: MTNR1B, Melatonin receptor type 1B
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分子量
- approx. 40 kDa
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基因ID
- 4544
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NCBI登录号
- NP_005950
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UniProt
- P49286
抗原
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