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S1PR2 抗体

This anti-S1PR2 antibody (ABIN317746) is a Rabbit Polyclonal antibody detecting S1PR2 in WB, IF, EIA. Suitable for Human, Mouse, Rat.
产品编号 ABIN317746
发货至: 中国

Quick Overview for S1PR2 抗体 (ABIN317746)

抗原

See all S1PR2 抗体
S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This S1PR2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
  • 特异性

    This antibody detects endogenous levels of EDG-5 protein.(region surrounding Leu300)

    交叉反应 (详细)

    Species reactivity (expected):Rat and Mouse.
    Species reactivity (tested):Human.

    纯化方法

    Affinity Chromatography using epitope-specific immunogen.
  • 应用备注

    ELISA: 1/40000approx. 1/60000. Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Pérez-Cerezales, Boryshpolets, Afanzar, Brandis, Nevo, Kiss, Eisenbach: "Involvement of opsins in mammalian sperm thermotaxis." in: Scientific reports, Vol. 5, pp. 16146, (2016) (PubMed).

    Duarte, Kobayashi, Kawamoto, Moriyama: "RELAXIN enhances differentiation and matrix mineralization through Relaxin/insulin-like family peptide receptor 2 (Rxfp2) in MC3T3-E1 cells in vitro." in: Bone, Vol. 65, pp. 92-101, (2015) (PubMed).

    Yao, Peng, Dai: "The role of hepatocyte nuclear factor 4alpha in metastatic tumor formation of hepatocellular carcinoma and its close relationship with the mesenchymal-epithelial transition markers." in: BMC cancer, Vol. 13, pp. 432, (2014) (PubMed).

    Wang, Li, Pan, Zhu, Wang: "Influence of hypercapnia on the synthesis of neuropeptides and their receptors in murine brain." in: Respirology (Carlton, Vic.), Vol. 18, Issue 1, pp. 102-7, (2013) (PubMed).

    Huang, Liu, Lan, Xie, Peng, Huang, Wang, Shen, Liu, Huang: "Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models." in: PLoS ONE, Vol. 7, Issue 8, pp. e43874, (2012) (PubMed).

    Niwa, Rowbotham, Lambert: "Evaluation of primary opioid receptor antibodies for use in western blotting." in: British journal of anaesthesia, Vol. 108, Issue 3, pp. 530-2, (2012) (PubMed).

  • 抗原

    S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

    别名

    EDG-5 / S1P2

    背景

    The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high-affinity. EDG-6 is a low-affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.Synonyms: AGR16, EDG5, Endothelial differentiation G-protein coupled receptor 5, Gpcr13, H218, LPB2, S1P receptor 2, S1PR2, Sphingosine 1-phosphate receptor 2

    分子量

    approx. 39 kDa

    基因ID

    9294

    NCBI登录号

    NP_004221

    UniProt

    O95136

    途径

    Synaptic Membrane
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