CCR7 抗体
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Quick Overview for CCR7 抗体 (ABIN317730)
抗原
See all CCR7 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of CD197 / CCR7 (CKR-7)(region surrounding Arg209).
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交叉反应 (详细)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity-chromatography
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应用备注
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ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))
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别名
- CD197 / CCR7
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背景
- C-C or β chemokine family members are characterized by a pair of adjacent cysteine residues and serve as potent chemoattractants and activators of monocytes and T cells. C-C chemokine receptor family members include CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7 and the Duffy blood group antigen. Each of these receptors are G protein-coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation. However, this receptor family has also been shown to facilitate viral infection. Termed a co-receptor, CKR-5, along with CD4, has been shown to be a major receptor for HIV. CKR-5 tends to associate with macrophagetropic viruses, such as macrophage tropic HIV-1, while CKR-2B and CKR-3 bind a minority of viruses.Synonyms: BLR2, C-C CKR-7, C-C chemokine receptor type 7, CC-CKR-7, CCR-7, CMKBR7, EBI1, EBV-induced G-protein coupled receptor 1, EVI1, MIP-3 beta receptor
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分子量
- approx. 43 kDa
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基因ID
- 1236
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NCBI登录号
- NP_001829
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UniProt
- P32248
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途径
- Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process
抗原
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