CHRM1 抗体
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北京 101111
Quick Overview for CHRM1 抗体 (ABIN317696)
抗原
See all CHRM1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Muscarinic acetylcholine receptor M1 / mAChR M1 protein (region surrounding Arg336).
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纯化方法
- Affinity-chromatography using epitope-specific immunogen
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应用备注
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ELISA: 1: 5000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 0.05 % Sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CHRM1 (Muscarinic Acetylcholine Receptor M1 (CHRM1))
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别名
- Muscarinic Acetylcholine Receptor M1
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背景
- The muscarinic acetylcholine receptors (mAChR) mediate a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels. The mAChRs transducer signals by coupling to G-proteins, which then modulate several downstream effector proteins and ion channels. Five mAChR subtypes have been identified, designated M1 to M5. The five receptor subtypes show distinct patterns of tissue distribution, as well as distinct pharmacological and functional properties. The amino acid sequence of each mAChR subtype reflects a structure that is characteristic of G-protein coupled receptors, consisting of seven highly conserved transmembrane segments and a large intracellular region unique to each subtype, which constitutes the effector-coupling domain.Synonyms: CHRM1, mAChR M1, mAChR-M1
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分子量
- Approx. 50 kDa
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基因ID
- 1128
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NCBI登录号
- NP_000729
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UniProt
- P11229
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途径
- Synaptic Membrane
抗原
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