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S1PR4 抗体

S1PR4 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN317690
发货至: 中国
  • 抗原 See all S1PR4 抗体
    S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))
    适用
    • 38
    • 29
    • 3
    • 2
    • 1
    • 1
    人, 小鼠
    宿主
    • 47
    • 6
    克隆类型
    • 49
    • 4
    多克隆
    标记
    • 26
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    This S1PR4 antibody is un-conjugated
    应用范围
    • 38
    • 16
    • 13
    • 13
    • 9
    • 9
    • 6
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    特异性
    This antibody detects endogenous levels of EDG-6 protein.(region surrounding Ser368)
    纯化方法
    Affinity Chromatography using epitope-specific immunogen.
    Top Product
    Discover our top product S1PR4 Primary Antibody
  • 应用备注
    ELISA: 1/20000approx. 1/40000. Western Blot: 1/500approx. 1/1000. Immunofluorescence: 1/50approx. 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))
    别名
    S1PR4 / EDG6 (S1PR4 产品)
    背景
    The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain.Synonyms: EDG-6, Endothelial differentiation G-protein coupled receptor 6, S1P receptor Edg-6, Sphingosine 1-phosphate receptor 4, Sphingosine 1-phosphate receptor Edg-6
    分子量
    approx. 40 kDa
    基因ID
    8698
    NCBI登录号
    NP_003766
    UniProt
    O95977
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