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G Protein-Coupled Receptor 119 抗体

GPR119 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN317642
发货至: 中国
  • 抗原 See all G Protein-Coupled Receptor 119 (GPR119) 抗体
    G Protein-Coupled Receptor 119 (GPR119)
    适用
    • 16
    • 6
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    • 2
    • 2
    • 1
    • 1
    宿主
    • 17
    • 1
    • 1
    克隆类型
    • 17
    • 1
    • 1
    多克隆
    标记
    • 19
    This G Protein-Coupled Receptor 119 antibody is un-conjugated
    应用范围
    • 12
    • 11
    • 11
    • 9
    • 5
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    特异性
    This antibody detects endogenous levels of GPR119 protein.(region surrounding Val227)
    纯化方法
    Affinity Chromatography using epitope-specific immunogen.
    Top Product
    Discover our top product GPR119 Primary Antibody
  • 应用备注
    ELISA: 1/1000-1/5000. Western Blot: 1/500-1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    G Protein-Coupled Receptor 119 (GPR119)
    别名
    GPR119 (GPR119 产品)
    别名
    GPR119 antibody, GPCR2 antibody, G protein-coupled receptor 119 antibody, G-protein coupled receptor 119 antibody, GPR119 antibody, gpr119 antibody, Gpr119 antibody
    背景
    G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intra cellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane- spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR119 is a 335 amino acid protein that is mainly expressed in the pancreas. It is an endogenous receptor for lysophosphatidylcholine (LPC), which is is a lipid mediator involved in insulin secretion from pancreatic cells. GPR119 may participate in this insulin secretion, suggesting that it may be potential target for new anti-diabetic drugs.Synonyms: G-protein coupled receptor 119, Glucose-dependent insulinotropic receptor
    分子量
    approx. 37 kDa
    基因ID
    139760
    NCBI登录号
    NP_848566
    UniProt
    Q8TDV5
    途径
    Hormone Transport, Peptide Hormone Metabolism
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