S1PR2 抗体
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北京 101111
Quick Overview for S1PR2 抗体 (ABIN317633)
抗原
See all S1PR2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of EDG-5 protein.(region surrounding Leu303)
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纯化方法
- Affinity Chromatography using epitope-specific immunogen
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anti-Sphingosine-1-Phosphate Receptor 2 (S1PR2) (AA 293-353) antibody
S1PR2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 2 (S1PR2) (C-Term) antibodyS1PR2 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 2 (S1PR2) (AA 39-73) antibodyS1PR2 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB53162 unconjugated
anti-Sphingosine-1-Phosphate Receptor 2 (S1PR2) (Internal Region) antibodyVerified S1PR2 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 2 (S1PR2) (Internal Region) antibodyS1PR2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 2 (S1PR2) (AA 272-298), (C-Term) antibodyS1PR2 适用: 人 WB 宿主: 兔 Polyclonal RB40507 unconjugated
anti-Sphingosine-1-Phosphate Receptor 2 (S1PR2) antibodyS1PR2 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 2 (S1PR2) (AA 272-298) antibodyS1PR2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine-1-Phosphate Receptor 2 (S1PR2) (2nd Cytoplasmic Loop), (AA 129-146) antibodyS1PR2 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000-1/20000. Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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: "N-acetyl-L-tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model." in: Neurobiology of disease, Vol. 80, pp. 93-103, (2015) (PubMed).
: "Application of RNA interference to improve mechanistic understanding of omics responses to a hepatotoxic drug in primary rat hepatocytes." in: Toxicology, Vol. 326, pp. 86-95, (2015) (PubMed).
: "CXCL12/CXCR4 axis confers adriamycin resistance to human chronic myelogenous leukemia and oroxylin A improves the sensitivity of K562/ADM cells." in: Biochemical pharmacology, Vol. 90, Issue 3, pp. 212-25, (2014) (PubMed).
: "Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility." in: The Journal of clinical investigation, Vol. 124, Issue 6, pp. 2571-84, (2014) (PubMed).
: "Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models." in: PLoS ONE, Vol. 7, Issue 8, pp. e43874, (2012) (PubMed).
: "Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration." in: American journal of physiology. Cell physiology, Vol. 298, Issue 3, pp. C550-8, (2010) (PubMed).
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- S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))
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别名
- EDG-5 / S1P2
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背景
- The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high-affinity. EDG-6 is a low-affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain. EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.Synonyms: AGR16, EDG5, Endothelial differentiation G-protein coupled receptor 5, Gpcr13, H218, LPB2, S1P receptor 2, S1PR2, Sphingosine 1-phosphate receptor 2
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分子量
- approx. 39 kDa
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基因ID
- 9294
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NCBI登录号
- NP_004221
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UniProt
- O95136
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途径
- Synaptic Membrane
抗原
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