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NAB2 抗体

This 兔 多克隆 antibody specifically detects NAB2 in WB 和 IHC (p). It exhibits reactivity toward 人 和 小鼠.
产品编号 ABIN317614
发货至: 中国
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Quick Overview for NAB2 抗体 (ABIN317614)

抗原

See all NAB2 抗体
NAB2 (NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2))

适用

  • 46
  • 34
  • 28
  • 7
  • 6
  • 6
  • 5
  • 5
  • 5
  • 3
  • 3
  • 2
人, 小鼠

宿主

  • 43
  • 7

克隆类型

  • 45
  • 5
多克隆

标记

  • 29
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This NAB2 antibody is un-conjugated

应用范围

  • 42
  • 12
  • 9
  • 6
  • 5
  • 4
  • 4
  • 2
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 特异性

    This antibody detects endogenous levels of NAB2 protein.(region surrounding Asp306)

    纯化方法

    Affinity Chromatography using epitope-specific immunogen
  • 应用备注

    Western Blot: 1/500-1/1000. ELISA: 1/10000-1/20000. Immunohistochemistry: 1/50-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH ~7.2 containing 15 mM Sodium Azide as preservative

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    NAB2 (NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2))

    别名

    NAB2

    背景

    Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.Synonyms: MADER, Melanoma-associated delayed early response protein, NGFI-A-binding protein 2

    分子量

    approx. 58.0 kDa

    基因ID

    4665

    NCBI登录号

    NP_005958

    UniProt

    Q15742
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