IL-33 抗体 (AA 112-270)
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Quick Overview for IL-33 抗体 (AA 112-270) (ABIN317536)
抗原
See all IL-33 (IL33) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 112-270
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特异性
- The antibody recognizes human IL-33. Other species not tested.
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产品特性
- Synonyms: IL-33, IL1F11, IL-1F11, NFHEV, NF-HEV, C9orf26, Interleukin-1 family member 11, Nuclear factorfrom high endothelial venules
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纯化方法
- Protein-G affinity chromatography
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免疫原
- Recombinant human IL-33 (112-270 aa) purified from E. coli
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亚型
- IgG2b
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应用备注
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ELISA. Western blot (1: 500 - 1: 2,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- IL-33 (IL33) (Interleukin 33 (IL33))
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别名
- Interleukin-33 (IL33)
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背景
- Interleukin 33 (IL-33) is a 32 kDa proinflammatory cytokine and intracellular nuclear factor with transcriptional regulatory properties. IL-33 is structurally related to IL-1, which induces helper T-cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12 kDa and C-terminal fragment of 18 kDa by cleavage of caspase-1.Synonyms: C9orf26, IL-1F11, IL-33, IL1F11, Interleukin-1 family member 11, NF-HEV, NFHEV, Nuclear factor from high endothelial venules
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基因ID
- 90865
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UniProt
- O95760
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途径
- Production of Molecular Mediator of Immune Response
抗原
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