SIRPA 抗体 (FITC)
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北京 101111
Quick Overview for SIRPA 抗体 (FITC) (ABIN317417)
抗原
See all SIRPA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
- Synonyms: BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP, P84, SHPS-1, Sirp-alpha-1, Sirp-alpha-2,Sirp-alpha-3, MyD-1, SHP Substrate 1, Tyrosine-Protein Phosphatase Non-Receptor TypeSubstrate 1, Inhibitory receptor SHPS-1, Signal-Regulatory Protein Alpha-1, Brain Ig-likeMolecule with Tyrosine-based Activation Motifs, Macrophage Fusion Receptor
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纯化方法
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
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免疫原
- Porcine alveolar macrophages
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亚型
- IgG1
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应用备注
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Flow Cytometry: use 10 μL of neat - 1/10 diluted antibody to label 1x10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.09 % Sodium Azide, 1 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2 - 8 °C up to one month or (in aliquots) at -20 °C forlonger. Avoid repeated freezing and thawing. This aproduct is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf life: one year from despatch. -
有效期
- 12 months
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- SIRPA (Signal-Regulatory Protein alpha (SIRPA))
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别名
- CD172a / SIRPA
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背景
- Protein tyrosine phosphatases (PTPases) SHP1 and SHP2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1),SHPS1 , MyD1, BIT and p84. SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP2. SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.Synonyms: BIT, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, MFR, MYD1, Macrophage fusion receptor, MyD-1 antigen, PTPNS1, SHP substrate 1, SHPS-1, SHPS1, Signal-regulatory protein alpha-1, Sirp-alpha-2, Sirp-alpha-3, Tyrosine-protein phosphatase non-receptor type substrate 1, p84
抗原
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