TRF1 抗体
Quick Overview for TRF1 抗体 (ABIN317052)
抗原
See all TRF1 (TERF1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60 kDa protein.
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产品特性
- Synonyms: PIN2, TRBF1, TRF, TRF1, Telomeric repeat-binding factor 1, TTAGGG repeat-binding factor 1,NIMA-interacting protein 2, Telomeric protein Pin2/TRF1
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纯化方法
- Purified IgG prepared by affinity chromatography on Protein G
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免疫原
- Recombinant TRF1
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亚型
- IgG1
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anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 148-428) antibody
TERF1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 240-419) antibodyTERF1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 260-439) antibodyTERF1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) antibodyTERF1 适用: 人 ELISA, IHC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal BED5 unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 1-439) antibodyTERF1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (pSer219) antibodyTERF1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (AA 260-439) antibodyTERF1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (C-Term) antibodyTERF1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1) (C-Term) antibodyVerified TERF1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections: 1/200 - 1/1000, This product requires antigenretrieval using heat treatment prior to staining of paraffin sections, Sodium citrate buffer pH 6.0 is recommended for this purpose. ELISA. Western Blot: detects a band of approximately 60 kDa in Jurkat whole cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS pH 7.4 containing 0.09 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled bytrained staff only. -
有效期
- 12 months
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- TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))
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别名
- TERF1
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背景
- Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. TRF1 is thought to play a role in leukaemia being expressed at significantly higher levels in patients with acute lymphoblastic leukaemia than those with myeloid leukaemia.Synonyms: NIMA-interacting protein 2, PIN2, TRBF1, TRF, TRF1, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1, Telomeric repeat-binding factor 1
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基因ID
- 7013
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UniProt
- P54274
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途径
- Cell Division Cycle, Telomere Maintenance, Hormone Transport, Chromatin Binding, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
抗原
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