MBP 抗体
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Quick Overview for MBP 抗体 (ABIN3071582)
抗原
See all MBP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Myelin Basic Protein Mouse Monoclonal Antibody
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特异性
- This antibody reacts with residues 130-136 in human myelin basic protein (21.5 kDa and 18.5 kDa molecular forms). It also recognizes primate, rabbit, sheep, goat, rat, and mouse myelin basic protein.
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交叉反应
- 山羊, 人, 小鼠, 灵长类, 兔, 大鼠, 绵羊
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免疫原
- Purified human myelin basic protein.
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亚型
- IgG2b
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应用备注
- This antibody may be used in ELISA, immunohistochemistry, and Western blot procedures for detection and/or quantitation of myelin basic protein.ELISA: Human myelin basic protein coated on ELISA wells at 5 μg/mL, binding detected with HRP-conjugated goat anti-mouse IgG + ABTS substrate.
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限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium that is identical to that used in the assay system.
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浓度
- Lot specific
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缓冲液
- PBS, pH 7.4
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储存条件
- -20 °C,-80 °C
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储存方法
- This antibody is stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
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- MBP (Myelin Basic Protein (MBP))
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别名
- Myelin Basic Protein
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背景
- Myelin basic protein,The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {PubMed:8544862}.,Myelin membrane, Peripheral membrane protein, Cytoplasmic side. Note=Cytoplasmic side of myelin., [Isoform 3]: Nucleus,MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein
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UniProt
- P02686
抗原
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