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- 抗原 See all SMPD1 抗体
- SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SMPD1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人
- 产品特性
- Acid Sphingomyelinase, aSMase, SMPD1, ASM, Sphingomyelin phosphodiesterase, ASM-1,Human acid sphingomyelinase (sphingomyelin phosphodiesterase, ASM) is the lysosomal enzyme responsible for the hydrolysis of sphingomyelin to ceramide and phosphocholine. Converts sphingomyelin to ceramide. aSM also has phospholipase C activities toward 1,2-diacylglycerol-phosphocholine and 1,2-diacylglycerol-phosphoglycerol. The enzyme is a membrane-associated glycoprotein with a pH optimum of about 4.5 and a subunit molecular mass of about 72 kDa. In addition AtoS M, two other sphingomyelinases have been identified in man, a Mg2+- dependent neutral sphingomyelinase found primarily in brain and a Zn2+-dependent acid sphingomyelinase found primarily in serum. Although it is likely that the acid and neutral sphingomyelinases are coded by different genes, the molecular genetic relationship of these three biochemically distinct sphingomyelinases has not been determined. Understanding the role of these sphingomyelinases in the hydrolysis of sphingomyelin to ceramide will be an important step in the understanding of ceramide as it is further hydrolyzed to sphingosine, a neutral phospholipid which has been implicated in the regulation of protein kinase C-mediated signal transduction. Inherited deficiencies of ASM have been reported in man, deficient ASM activity results in the two major subtypes of Niemann-Pick disease (NPD).
- 纯化方法
- Ammonium Sulfate Precipitation
- 免疫原
- Rabbits were immunized with a synthetic peptide derived from human acid sphingomyelinase protein.
- Top Product
- Discover our top product SMPD1 Primary Antibody
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anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 391-419), (C-Term) antibody
SMPD1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB31029 unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 319-579) antibodySMPD1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 70-340) antibodySMPD1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) antibodySMPD1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 1-364) antibodySMPD1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H2 unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 391-419), (C-Term) antibodySMPD1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 201-300) antibodySMPD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 391-419) antibodySMPD1 适用: 人 WB, IHC, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) (AA 396-445) antibodySMPD1 适用: 人, 小鼠, 大鼠, Cow, 绵羊, 兔, 犬, 马, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Antibody can be used for Western blots (5-10 μg/mL) and ELISA. Optimal concentration should be evaluated by serial dilutions.
- 限制
- 仅限研究用
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- 缓冲液
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- 抗原
- SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))
- 别名
- Acid Sphingomyelinase (SMPD1 产品)
- 别名
- ASM antibody, ASMASE antibody, NPD antibody, A-SMase antibody, Zn-SMase antibody, aSMase antibody, SMPD1 antibody, sphingomyelin phosphodiesterase 1 antibody, sphingomyelin phosphodiesterase 1, acid lysosomal antibody, sphingomyelin phosphodiesterase antibody, SMPD1 antibody, Smpd1 antibody, LOC5578088 antibody
- UniProt
- P17405
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