SPHK1 抗体 (C-Term)
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北京 101111
Quick Overview for SPHK1 抗体 (C-Term) (ABIN306932)
抗原
See all SPHK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应
- Cow, 人, 小鼠, 大鼠
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产品特性
- EC 2.7.1, SK 1, SPK 1, SPHK1, Gene name: SPHK1 or SPHK or SP,Sphingosine Kinase 1 (Sphk1) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
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纯化方法
- Antigen Immunoaffiinity Purification
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免疫原
- Rabbits were immunized with a synthetic peptide derived from the C-terminal of human Sphingosine Kinase 1
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亚型
- IgG
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anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibody
SPHK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D6 unconjugated
anti-Sphingosine Kinase 1 (SPHK1) (AA 286-315) antibodySPHK1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB03621 unconjugated
anti-Sphingosine Kinase 1 (SPHK1) (AA 286-315) antibodySPHK1 适用: 人, 小鼠, 大鼠, 灵长类 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine Kinase 1 (SPHK1) (AA 313-343) antibodySPHK1 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine Kinase 1 (SPHK1) (AA 148-398) antibodySPHK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine Kinase 1 (SPHK1) (AA 50-384) antibodySPHK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine Kinase 1 (SPHK1) (AA 1-384) antibodySPHK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine Kinase 1 (SPHK1) (AA 1-30), (N-Term) antibodySPHK1 适用: 人 WB 宿主: 兔 Polyclonal RB3619 unconjugated
anti-Sphingosine Kinase 1 (SPHK1) (AA 59-89) antibodySPHK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sphingosine Kinase 1 (SPHK1) (AA 1-30) antibodySPHK1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Antibody can be used for Western blotting (1:400 dilution) and ELISA. Other applications not yet tested. Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- SPHK1 (Sphingosine Kinase 1 (SPHK1))
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别名
- Sphingosine Kinase 1
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UniProt
- Q9NYA1
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途径
- VEGF Signaling
抗原
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