Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) 抗体
The 兔 多克隆 anti-Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) antibody is suitable to detect Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) in samples from 人. It has been validated for WB.
产品编号 ABIN306920
发货至:
中国
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Quick Overview for Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) 抗体 (ABIN306920)
抗原
Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6)
适用
人
宿主
兔
克隆类型
多克隆
应用范围
Western Blotting (WB)
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原理
- Rabbit anti Human Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6) NT
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交叉反应
- 人
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产品特性
- EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine 1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs.
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纯化方法
- Ammonium Sulfate Precipitation
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亚型
- IgG
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应用备注
- Detects EDG6 (S1P4) receptors at concentration of 5-10 μg/mL by Western blot using a human EDG6 (S1P4) receptor transfected cell line. Detects an approximately 45 kDa band in Cos cells transfected with full length human EDG6 (S1P4) . Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development.
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限制
- 仅限研究用
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- Sphingosine 1 Phosphate 4 Receptor (NT) (EDG6)
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背景
- Endothelial cell differentiation gene 6, N terminal, Sphingosine 1-Phosphate Receptor-4 (S1P4)
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UniProt
- O95977
抗原
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