Sphingosine 1 Phosphate 3 Receptor (EDG-3) 抗体
The 兔 多克隆 anti-Sphingosine 1 Phosphate 3 Receptor (EDG-3) antibody is suitable to detect Sphingosine 1 Phosphate 3 Receptor (EDG-3) in samples from 人 和 小鼠. It has been validated for IP 和 WB.
产品编号 ABIN306917
发货至:
中国
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Quick Overview for Sphingosine 1 Phosphate 3 Receptor (EDG-3) 抗体 (ABIN306917)
抗原
Sphingosine 1 Phosphate 3 Receptor (EDG-3)
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Immunoprecipitation (IP), Western Blotting (WB)
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原理
- x1327k2
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交叉反应
- 人, 小鼠
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产品特性
- Endothelial cell differentation gene-3 (EDG3) belongs to a family of G-protein couple receptors whose ligands are lysophospholipids. The ligand for EDG3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family. They have been implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG3 is expressed in cardiovascular, leukocyte-containing and other tissues.
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纯化方法
- Ammonium Sulfate Precipitation
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应用备注
- Antibody can be used for Western blotting (5-10 μg/mL) and Immunoprecipitation (see reference 4). Optimal concentration should be evaluated by serial dilutions. Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development.
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限制
- 仅限研究用
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- Sphingosine 1 Phosphate 3 Receptor (EDG-3)
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背景
- Endothelial cell differentiation gene 3 C-terminal, Sphingosine-1-Phosphate Receptor-3 (S1P3)
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UniProt
- Q99500
抗原
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