APCS 抗体 (full length)
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北京 101111
Quick Overview for APCS 抗体 (full length) (ABIN306863)
抗原
See all APCS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- full length
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原理
- Rabbit anti Human SH21A (SH2 DOMAIN-CONTAINING PROTEIN 1A) / (SAP)
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交叉反应
- 人
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产品特性
- SLAM (Signaling Lymphocyte-Activation Molecule) is a glycosylated type-I transmembrane protein which is present on the surface of B and T cells. SLAM is a high-affinity self-ligand which, when triggered, co-activated B or T lymphocyte responses and is considered to be important in bi-directional T - B cell stimulation. SAP (SLAM-Associated Protein) has been determined to be a 15 kDa protein. SAP is believed to the genetic defect which cauases X-linked Lymphoproliferative Syndrome (XLP). SAP is thought to bind to SLAM by the SH2 domain of the SAP protein. Binding of SAP to the SLAM protein blocks the binding of SHP-2 to the phosphorylated SLAM protein which causes XLP.
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- Full-length recombinant SAP protein
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亚型
- IgG
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应用备注
- This antibody can be used for Western blotting (5-10 μg/mL) and immunoprecipiation. Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- APCS (Amyloid P Component, Serum (APCS))
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别名
- SAP
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背景
- SAP, DSHP, SLAM ASSOCIATED PROTEIN
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UniProt
- O60880
抗原
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