Fibronectin 抗体
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北京 101111
Quick Overview for Fibronectin 抗体 (ABIN306829)
抗原
See all Fibronectin 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Mouse anti Human Fibronectin
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交叉反应
- 人, 小鼠
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产品特性
- Fibronectins are a family of plasma and extracellular matrix glycoproteins that contain multiple sites for various ligands and cells. The region of fibronectin that mediates cell adhesion in a majority of cell types is in the carboxy terminal domain and involves the binding of the Arg-Gly-Asp (RGD) sequence to a specific polypeptide cell surface receptor. Although the mechanisms of fibronectin extracellular matrix assembly are not well understood, specific antibodies have been used to determine the domains involved in matrix assembly. This antibody stains the extracellular adhesive glycoprotein of fibronectin in connective tissues and vessels. It does not recognize the soluble dimeric form of fibronectin (plasma fibronectin) but strongly stains matrix fibronectin in tissues. Animal biodistribution experiments have shown that after intravenous administration, this antibody localizes to tumor vessels where it binds to the underlying basement membrane. The antigen is not accessible in normal tissues to circulating antibody indicating that this antibody can be used to target tumor vessels specifically in vivo.
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纯化方法
- Protein A/G Chromatography
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亚型
- IgG1
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anti-Fibronectin (AA 1201-1300) antibody
适用: 人, 大鼠, 小鼠, Cow WB, ELISA, ICC, IHC (p), IF (p), IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 355-558) antibody适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 2117-2236) antibody适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 313-607) antibody适用: 人 WB, IHC, ICC, IP, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 1998-2106) antibody适用: 人 WB, IHC, ICC, IP, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 2240-2280) antibody适用: 人, 大鼠, 小鼠 WB, IHC (p), IF (p) 宿主: 小鼠 Monoclonal 1B9 unconjugated
anti-Fibronectin (AA 355-558) antibody适用: 大鼠 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Fibronectin (AA 510-689) antibody适用: 小鸡 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 2206-2337) antibody适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin antibodyKD Validated 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
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应用备注
- Antibody can be used for staining of human and mouse frozen and paraffin-embedded tissue sections. Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- Fibronectin
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背景
- Fibronectin
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UniProt
- P02751
抗原
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