Farnesyl 抗体
The 兔 多克隆 anti-Farnesyl antibody (ABIN306789) specifically detects Farnesyl in IF 和 ELISA.
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产品编号 ABIN306789
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Farnesyl 抗体 (ABIN306789)
抗原
Farnesyl
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Immunofluorescence (IF), ELISA
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产品特性
- Protein isoprenylation is a post-translational modification that affects about 0.5 % of cellular proteins and is essential for the biological activity of proteins. Two enzymes catalyze the attachment of two prenyl groups to the sulfhydryl group of carboxyl-terminal cysteine groups. Proteins which are prenylated by these enzymes have a distinct motif at the C-terminal of the protein, C-A1-A2-X (C = Cysteine, A1 & A2 = aliphatic amino acids). The two enzymes involved in this transfer are farnesyltransferase and geranylgeranyltransferase. These transfer a 15 carbon farnesyl or a 20 carbon geranygeranyl, respectively, from a prenyl-pyrophosphate to the protein. Examples of proteins containing this C-A-A-X motif are members of the Ras small G protein family, the nuclear lamins and the gamma subunit of trimeric G proteins. Prenylation of proteins is necessary for membrane association of proteins as well as protein-protein interactions and the nature of the linked isoprenyl group can influence the protein interactions, such as the interaction between G proteins and receptors.
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- Rabbit immunized with farnesyl cysteine conjugated to KLH.
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亚型
- IgG
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anti-Farnesyl antibody
IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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缓冲液
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- Farnesyl
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物质类
- Chemical
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UniProt
- P14324
抗原
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