PIG3 (p53 Inducible Gene 3) (full length) 抗体
The 兔 多克隆 anti-PIG3 (p53 Inducible Gene 3) antibody is suitable to detect PIG3 (p53 Inducible Gene 3) in samples from 人. It has been validated for WB.
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产品编号 ABIN306782
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for PIG3 (p53 Inducible Gene 3) (full length) 抗体 (ABIN306782)
抗原
PIG3 (p53 Inducible Gene 3)
适用
人
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB)
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抗原表位
- full length
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原理
- Rabbit anti Human PIG3 (p53 inducible gene 3)
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交叉反应
- 人
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产品特性
- p53 inducible gene-3 (PIG-3) may be a long-lived reporter, which may be useful for detecting transient activation of p53. The p53 tumor suppressor is the most commonly mutated gene in human cancers. The p53 protein, which is stabilized in response to different biological checkpoints, is activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in efects such as cell cycle arrest, apoptosis, senescence, differentiation, and antiangiogenesis. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others. The p53-inducible gene 3 (PIG3), was recently identified in a screen for genes induced by p53 before the onset of apoptosis. PIG3 shares significant homology with the oxidoreductases from several species. PIG3 protein is localized to the cytoplasm and induced in primary, non-transformed, and transformed cell cultures after exposure to genotoxic agents. The induction of PIG3 by p53 occurrs with delayed kinetics as compared with other p53 downstream targets, such as p21 and MDM2. PIG3 levels are increased during p53-mediated growth arrest. Elevated levels of PIG3 are maintained in cells that resume cycling in the absence of ectopic p53 expression.
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- Antibody developed using full-length recombinant PIG-3 protein.
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亚型
- IgG
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anti-PIG3 (p53 Inducible Gene 3) antibody
适用: 人 WB 宿主: 小鼠 Monoclonal 10A2 unconjugated
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应用备注
- Detects recombinant PIG-3 protein by Western blot. Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- PIG3 (p53 Inducible Gene 3)
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背景
- Putative quinone oxidoreductase, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein, TP53I3, PIG3
抗原
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