LEF-1 Alternate Exon 抗体
This 小鼠 单克隆 antibody specifically detects LEF-1 Alternate Exon in WB. It exhibits reactivity toward 人.
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产品编号 ABIN306724
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for LEF-1 Alternate Exon 抗体 (ABIN306724)
抗原
LEF-1 Alternate Exon
适用
人
宿主
小鼠
克隆类型
单克隆
应用范围
Western Blotting (WB)
克隆位点
1C3
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交叉反应
- 人
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产品特性
- Mouse Anti Lef-1, Lymphoid Enhancer Factor 1,Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. This antibody is specific for an epitope between a.a. 227-231. This sequence lies within the context dependent activation domain of LEF-1 and appears to be an alternate splice variant exon of the LEF-1 gene
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纯化方法
- Protein A/G Chromatography
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免疫原
- Recombinant full-length LEF-1 protein
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亚型
- IgG1
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应用备注
- Detect LEF-1 protein containing the alternately spliced exon between amino acids 212-241 by Western blot at 1-5 μg/mL. Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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缓冲液
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- LEF-1 Alternate Exon
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UniProt
- Q9UJU2
抗原
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