PPP4R1 抗体 (AA 1-205)
Quick Overview for PPP4R1 抗体 (AA 1-205) (ABIN306662)
抗原
See all PPP4R1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-205
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交叉反应 （详细）
- Human, mouse, rat
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产品特性
- Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1, Protein Phosphatase X/A'2, PP4R1,Clone 4A4 binds to all known Isotypes of p63. It is known as an excellent marker of basal cells in squamous epithelia and transitional cell epithelia (localisation of the antigen in cell nuclei). It is well suited for the detection of squamous cell carcinoma. In prostate tissue 80 % of basal cells in benign tissue react positive, whereas p63 disappears in prostate carcinoma. The p63 gene is a homologue of the tumour suppressor gene p53. It is highly expressed in nuclei of basal cells, the progenitor cells of many epithelial tissues. It shows up remarkable structural similarities to p53. By alternative splicing at least 6 different isoforms are synthesised, which are different in the C-terminus (alpha, beta, gamma) and in the N-terminus (TA and DN). In mice loss of the p63 gene leads to inability to form basal cells and severe organic deficits. Similar organic failures occur in humans with autosomal dominant EEC-Syndrome, which obviously is related to mutation of the p63 gene. p63 (6 Isotypes).
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免疫原
- Recombinant p63 Protein (AA 1-205) N-terminal part of deltaNp63
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亚型
- IgG
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anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (AA 324-647) antibody
PPP4R1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (N-Term) antibodyPPP4R1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (AA 114-348) antibodyPPP4R1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1) (Center) antibodyPPP4R1 适用: 人, 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Pre-treatment of formaldehyde-fixed tissue with Tris-buffered EDTA solution pH 9 or Unmasking Fluid G 40 min at 100 °C,IHC(P),60 min at RT,(liquid conc.) 1:25-1:50
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限制
- 仅限研究用
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缓冲液
- Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide. The volume is sufficient for 250-500 immunohistochemical tests (100 μL working solution / test). Use appropriate antibody diluent
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C
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- PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))
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别名
- Protein Phosphatase 4 R1 (X/A'2)
抗原
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