MAGI (PDZ 4-5) 抗体
This 绵羊 多克隆 antibody specifically detects MAGI (PDZ 4-5) in WB. It exhibits reactivity toward 人.
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产品编号 ABIN306589
发货至:
中国
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Contact Info
Our Local Distributor
中国
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北京 101111
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Quick Overview for MAGI (PDZ 4-5) 抗体 (ABIN306589)
抗原
MAGI (PDZ 4-5) (MAGI)
(Membrane AssociatedGuanalyate Kinase (PDZ 4-5) (MAGI))
适用
人
宿主
绵羊
克隆类型
多克隆
应用范围
Western Blotting (WB)
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原理
- Sheep anti Human Guanalyate Kinase (PDZ 4-5) (MAGI)
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产品特性
- Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is then followed by 6 PDZ domains.
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- Recombinant protein corresponding to PDZ domains 4-5 of MAGI-3.
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亚型
- IgG
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应用备注
- Antibody detects MAGI-3 by Western blot at 1-10 μg/mL. Detects a 130 kDa band in cells transfected with full-length MAGI-3 protein. Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/ml
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缓冲液
- phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- MAGI (PDZ 4-5) (MAGI) (Membrane AssociatedGuanalyate Kinase (PDZ 4-5) (MAGI))
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背景
- Sheep anti-Membrane-associated guanylate cyclase of inverted orientation-3, PSD95 DiscsLarge Z01 domains 4-5
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UniProt
- Q9H2V6
抗原
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