MUC16 抗体 (Extracellular Domain)
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Quick Overview for MUC16 抗体 (Extracellular Domain) (ABIN305131)
抗原
See all MUC16 (CA125) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Extracellular Domain
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特异性
- Recognizes the ovarian cancer mucin CA125 (also known as MUC16). CA125 consists of a short cytoplasmic tail, a transmembrane domain and an exceptionally large glycosylated extracellular domain. The extracellular domain is dominated by a large number of 156-amino acid repeat units, over 60 in all. These repeats are known to bind the antibodies OC125 and M11. CA125 is present within normal ovarian, endometrium, endocervix and fallopian tissue, but levels are elevated in over 90 % of women with advanced ovarian cancer. CA125 levels may also be elevated in other cancers and non-cancerous conditions such as peritonitis, endometriosis and liver cirrhosis. Levels may also fluctuate during the menstrual cycle and occasionally increases in pregnancy, making CA125 an unreliable marker for ovarian cancer in premenopausal women. The function of CA125 in healthy tissue is unknown but it is thought to provide a protective lubricating barrier against particles and infectious agents at mucosal surfaces. CA125 was concluded by the International Society of Oncology and BioMarkers (ISOBM) to contain two major antigenic domains. Recognizes the epitope specificity group B, similar to the M-11 antibody. May be used as a capture antibody in ELISA assays.
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纯化方法
- Ion exchange chromatography
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免疫原
- CA125 antigen purified from human ovarian carcinoma.
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亚型
- IgG1
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anti-Mucin 16, Cell Surface Associated (CA125) (AA 1-200) antibody
CA125 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 4C8C8 unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) (AA 13977-14117) antibodyCA125 适用: 人 IHC, WB, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) antibodyCA125 适用: 人 IHC 宿主: 兔 Monoclonal OCA125-2349R unconjugated Recombinant Antibody
anti-Mucin 16, Cell Surface Associated (CA125) (AA 2-258) antibodyCA125 适用: 小鼠 IHC, WB, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) (AA 14067-14328) antibodyCA125 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) (AA 10329-10628) antibodyCA125 适用: 人 IHC, WB, IHC (p) 宿主: 小鼠 Monoclonal 3B6 unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) (AA 10329-10628) antibodyCA125 适用: 人 IHC, WB, IHC (p) 宿主: 小鼠 Monoclonal 2C4 unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) antibodyCA125 适用: 人 IHC 宿主: 小鼠 Monoclonal MUC16-1860 unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) antibodyCA125 适用: 人 IHC, IHC (p), HIER 宿主: 小鼠 Monoclonal Ov185:1 unconjugated
anti-Mucin 16, Cell Surface Associated (CA125) (AA 13311-13360) antibodyCA125 适用: 人 IHC, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Approved: ELISA, WB
Usage: ELISA: This product may be used in an indirect ELISA or as a detection antibody in a sandwich ELISA together with LS-B2829 as a capture reagent. -
说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Tris buffered saline, 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
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Short term: -20°C
Long term: -20°C.
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- MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))
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别名
- MUC16 / CA125
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背景
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Name/Gene ID: MUC16
Synonyms: MUC16, CA125 ovarian cancer antigen, CA125, CA-125, MUC-16, Mucin-16 -
基因ID
- 94025
抗原
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