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SKAP1 抗体 (Middle Region)

This anti-SKAP1 antibody is a 兔 多克隆 antibody detecting SKAP1 in WB 和 IHC. Suitable for 人 和 大鼠.
产品编号 ABIN3044545
发货至: 中国

Quick Overview for SKAP1 抗体 (Middle Region) (ABIN3044545)

抗原

See all SKAP1 抗体
SKAP1 (Src Kinase Associated phosphoprotein 1 (SKAP1))

适用

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人, 大鼠

宿主

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克隆类型

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多克隆

标记

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This SKAP1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

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    AA 163-189, Middle Region

    原理

    Anti-SKAP55/SKAP1 Antibody Picoband®

    序列

    RMAPHLRRDS KKESCFELTS QDRRSYE

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-SKAP55/SKAP1 Antibody Picoband® (ABIN3044545). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence in the middle region of human SKAP55, different from the related mouse and rat sequences by two amino acids.

    亚型

    IgG
  • 应用备注

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. "Entrez Gene: SKAP1 src kinase associated phosphoprotein 1". 2. Marie-Cardine A, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer SC, Schraven B (July 1997). "Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes". J Biol Chem 272 (26): 16077-80. 3. Wang H, Moon EY, Azouz A, et al. (2003). "SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates". Nat. Immunol. 4 (4): 366-74.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原

    SKAP1 (Src Kinase Associated phosphoprotein 1 (SKAP1))

    别名

    SKAP1

    背景

    Synonyms: Src kinase-associated phosphoprotein 1,Src family-associated phosphoprotein 1,Src kinase-associated phosphoprotein of 55 kDa,SKAP-55,pp55,SKAP1,SCAP1, SKAP55,

    Tissue Specificity: Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). .

    Background: Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene. This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.

    分子量

    60 kDa

    基因ID

    8631
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