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Prokineticin 1 抗体 (AA 20-105)

Prok1 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3044537
发货至: 中国
  • 抗原 See all Prokineticin 1 (Prok1) 抗体
    Prokineticin 1 (Prok1)
    抗原表位
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    AA 20-105
    适用
    • 36
    • 8
    • 5
    • 2
    小鼠
    宿主
    • 30
    • 8
    • 4
    • 2
    克隆类型
    • 36
    • 8
    多克隆
    标记
    • 26
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Prokineticin 1 antibody is un-conjugated
    应用范围
    • 24
    • 18
    • 13
    • 10
    • 10
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    原理
    Anti-Prokineticin 1/PROK1 Antibody Picoband®
    交叉反应 (详细)
    No cross-reactivity with other proteins.
    产品特性
    Anti-Prokineticin 1/PROK1 Antibody Picoband® (ABIN3044537). Tested in WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    E. coli-derived mouse Prokineticin 1 recombinant protein (Position: A20-F105). Mouse Prokineticin 1 shares 88.4% and 94.2% amino acid (aa) sequence identity with human and rat Prokineticin 1, respectively.
    亚型
    IgG
    Top Product
    Discover our top product Prok1 Primary Antibody
  • 应用备注
    Western blot, 0.1-0.5 μg/mL, Mouse
    1. LeCouter, J., Kowalski, J., Foster, J., Hass, P., Zhang, Z., Dillard-Telm, L., Frantz, G., Rangell, L., DeGuzman, L., Keller, G.-A., Peale, F., Gurney, P., Hillan, K. J., Ferrara, N. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature 412: 877-884, 2001. 2. Li, M., Bullock, C. M., Knauer, D. J., Ehlert, F. J., Zhou, Q. Y. Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle. Molec. Pharm. 59: 692-698, 2001.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Yu, Chen, Jiang: "Administration of pigment epithelium-derived factor delivered by adeno-associated virus inhibits blood-retinal barrier breakdown in diabetic rats." in: Molecular vision, Vol. 16, pp. 2384-94, (2011) (PubMed).

  • 抗原
    Prokineticin 1 (Prok1)
    别名
    PROK1 (Prok1 产品)
    背景

    Synonyms: Prokineticin-1 ,Endocrine-gland-derived vascular endothelial growth factor ,EG-VEGF ,Prok1 ,Pk1 ,

    Tissue Specificity: Highly expressed in liver and ovary and weakly expressed in testis and placenta. Expressed in mucosa and mesenchyme of embryonic gut during enteric nervous system development (at protein level). Predominantly expressed in kidney and liver. Also expressed in lung, ovary, placenta and testis. In fetal liver, is restricted to and highly expressed in hepatocytes. In adult kidney, expression is restricted to the endothelial tubule cells. In placenta, expressed throughout gestation. .

    Background: Prokineticin-1 is also known as EG-VEGF. The International Radiation Hybrid Mapping Consortium mapped the PROK1 gene to chromosome 1. The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner.

    分子量
    12 kDa
    基因ID
    246691
    UniProt
    Q14A28
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