Cathepsin K 抗体 (AA 115-329)
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Quick Overview for Cathepsin K 抗体 (AA 115-329) (ABIN3044511)
抗原
See all Cathepsin K (CTSK) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 115-329
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原理
- Anti-Cathepsin K/CTSK Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Cathepsin K/CTSK Antibody (ABIN3044511). Tested in IHC, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.
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亚型
- IgG
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anti-Cathepsin K (CTSK) (AA 54-317) antibody
CTSK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin K (CTSK) (AA 163-274) antibodyCTSK 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal CTSK-2791 unconjugated
anti-Cathepsin K (CTSK) (AA 220-329) antibodyCTSK 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Cathepsin K (CTSK) (AA 115-329) antibodyCTSK 适用: 人 WB 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Cathepsin K (CTSK) (AA 71-319) antibodyCTSK 适用: 犬 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin K (CTSK) (AA 115-329) antibodyCTSK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin K (CTSK) (AA 220-331) antibodyCTSK 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Cathepsin K (CTSK) (AA 115-329) antibodyCTSK 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin K (CTSK) (N-Term) antibodyCTSK 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cathepsin K (CTSK) (AA 97-126) antibodyCTSK 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB19253 unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Cathepsin K (CTSK)
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别名
- CTSK
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背景
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Synonyms: Cathepsin K,3.4.22.38,Cathepsin O,Cathepsin O2,Cathepsin X,CTSK,CTSO, CTSO2,
Tissue Specificity: Predominantly expressed in osteoclasts (bones).
Background: Cathepsin K, abbreviated?CTSK, is an?enzyme?that in humans is encoded by the?CTSK?gene. It is mapped to 1q21. The protein encoded by this gene is a lysosomal?cysteine protease?involved in bone remodeling and resorption. And this protein, which is a member of the peptidase C1 protein family, is expressed predominantly in?osteoclasts. Additionally, the enzyme's ability to catabolize?elastin,?collagen, and?gelatin?allow it to break down?bone?and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil inemphysema. Cathepsin K?inhibitors, such as?odanacatib, show great potential in the treatment of?osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.
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分子量
- 45 kDa
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基因ID
- 1513
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UniProt
- P43235
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途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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