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PROC 抗体 (C-Term)

Name: PROC 抗体 (C-Term)
SKU: ABIN3044486
Availability: OutOfStock

PROC 适用: 人 WB, IHC, ICC, FACS 宿主: 兔 Polyclonal unconjugated

Anti-Protein C antibody, Western blotting Lane 1: JURKAT Cell Lysate Lane 2: CEM Cell Lysate Lane 3: SMMC Cell Lysate Lane 4: HELA Cell Lysate (PROC 抗体 (C-Term))

Anti-Protein C antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue (PROC 抗体 (C-Term))

IHC

IHC analysis of Protein C using anti- Protein C antibody . (PROC 抗体 (C-Term))

IHC

3 images

(10 references)

产品编号 ABIN3044486

发货至: 中国

Datasheet as PDF

抗原 See all PROC 抗体

PROC (Vitamin K-dependent protein C (PROC))
抗原表位
7

5

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 446-461, C-Term
适用
82

13

7

2

2

1

1

1

1
人
宿主
58

17

10

3

3

1

1
兔
Compatible Secondaries
克隆类型
64

28

1
多克隆
标记
62

5

4

4

3

2

2

2

2

2

2

2

1
This PROC antibody is un-conjugated
应用范围
58

42

28

22

16

15

9

7

5

3

3

3

2

2

2

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

原理

Anti-Protein C/PROC Antibody Picoband®

序列

HGHIRDKEAP QKSWAP

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Protein C/PROC Antibody (ABIN3044486). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human Protein C.

亚型

IgG

Top Product

Discover our top product PROC Primary Antibody
anti-Vitamin K-dependent protein C (PROC) (AA 32-131) antibody
PROC 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3A10 unconjugated

anti-Vitamin K-dependent protein C (PROC) antibody
PROC 适用: 人 ELISA, IHC, IHC (p), IEP 宿主: 山羊 Polyclonal unconjugated

anti-Vitamin K-dependent protein C (PROC) (AA 1-236) antibody
PROC 适用: 人 WB, IHC, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Vitamin K-dependent protein C (PROC) antibody
PROC 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Vitamin K-dependent protein C (PROC) (Middle Region) antibody
PROC 适用: 人, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Vitamin K-dependent protein C (PROC) antibody
PROC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Vitamin K-dependent protein C (PROC) (AA 197-436) antibody
PROC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Vitamin K-dependent protein C (PROC) (AA 288-409) antibody
PROC 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Vitamin K-dependent protein C (PROC) antibody
PROC 适用: 人 ELISA, Purif, BP 宿主: 小鼠 Monoclonal HPC-4 unconjugated Recombinant Antibody

anti-Vitamin K-dependent protein C (PROC) (AA 1-166) antibody
PROC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E6 unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human
Immunocytochemistry, 0.5-1 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human1. Allaart, C. F., Poort, S. R., Rosendaal, F. R., Reitsma, P. H., Bertina, R. M., Briet, E. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet 341: 134-138, 1993. 2. Beckmann, R. J., Schmidt, R. J., Santerre, R. F., Plutzky, J., Crabtree, G. R., Long, G. L. The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs. Nucleic Acids Res. 13: 5233-5247, 1985. 3. Berg, L.-P., Scopes, D. A., Alhaq, A., Kakkar, V. V., Cooper, D. N. Disruption of a binding site for hepatocyte nuclear factor 1 in the protein C gene promoter is associated with hereditary thrombophilia. Hum. Molec. Genet. 3: 2147-2152, 1994.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
Liu, An, Liu, Li, Tang, Chen: "Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses." in: Antiviral research, Vol. 120, pp. 101-11, (2015) (PubMed).

Li, Wang, Zhao, Yang, Li, Zhao, Yu, Wang, Meng, Liu, Zhu, Gao, Jia, Yang: "Nuclear factor of activated T cells 5 maintained by Hotair suppression of miR-568 upregulates S100 calcium binding protein A4 to promote breast cancer metastasis." in: Breast cancer research : BCR, Vol. 16, Issue 5, pp. 454, (2015) (PubMed).

Ban, Fan, Huang, Li, Chen, Zhang, Xu: "Mono-(2-ethylhexyl) phthalate induces injury in human umbilical vein endothelial cells." in: PLoS ONE, Vol. 9, Issue 5, pp. e97607, (2014) (PubMed).

Tang, Li, Yu, Gao, Liu, Chen, Xing, Liu, Yao: "Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway." in: The Journal of nutritional biochemistry, Vol. 25, Issue 6, pp. 675-82, (2014) (PubMed).

Zhang, Zhang, Goldstein, Li, Ge, He, Ruiz: "The effect of c-fos on acute myocardial infarction and the significance of metoprolol intervention in a rat model." in: Cell biochemistry and biophysics, Vol. 65, Issue 2, pp. 249-55, (2013) (PubMed).

Aksu, Baykara, Kiray, Gurpinar, Sisman, Ekerbicer, Tas, Gokdemir-Yazar, Uysal: "Serum IGF-1 levels correlate negatively to liver damage in diabetic rats." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 88, Issue 3-4, pp. 194-201, (2013) (PubMed).

Chen, Liu, Yang, Leng: "Characterization of bmp15 and its regulation by human chorionic gonadotropin in the follicle of gibel carp (Carassius auratus gibelio)." in: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, Vol. 163, Issue 1, pp. 121-8, (2012) (PubMed).

Yang, Gu, Zheng, Li, Lian, Miao, Jiang, Wei: "RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11865-74, (2011) (PubMed).

Bao, Liu, Qin, Xu, Hei, Jaber, Chen: "An immunohistochemical study of S-100 protein in the intestinal tract of Chinese soft-shelled turtle, Pelodiscus sinensis." in: Research in veterinary science, Vol. 91, Issue 3, pp. e16-24, (2011) (PubMed).

Zhang, He, Goldstein, Ge, Wang, Ruiz: "The expression and significance of proto-oncogene c-fos in viral myocarditis." in: Virology journal, Vol. 7, pp. 285, (2010) (PubMed).
抗原

PROC (Vitamin K-dependent protein C (PROC))

别名

PROC (PROC 产品)

物质类

Viral Protein

背景

Synonyms: Vitamin K-dependent protein C,3.4.21.69,Anticoagulant protein C,Autoprothrombin IIA,Blood coagulation factor XIV,Vitamin K-dependent protein C light chain,Vitamin K-dependent protein C heavy chain,Activation peptide,PROC,
Tissue Specificity: Plasma, synthesized in the liver.
Background: Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated protein C concentrates had been described in case reports and in 1 uncontrolled series.
Sequence Similarities: Belongs to the peptidase S1 family.

分子量

36 kDa

UniProt

P04070