PIAS1 抗体 (C-Term)
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北京 101111
Quick Overview for PIAS1 抗体 (C-Term) (ABIN3044474)
抗原
See all PIAS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-E3 SUMO-protein ligase PIAS1 PIAS1 Antibody
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序列
- DTASIFGIIP DIISLD
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- identical to the related mouse,rat sequences.
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产品特性
- Anti-E3 SUMO-protein ligase PIAS1 PIAS1 Antibody. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human PIAS1, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (N-Term) antibody
PIAS1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 636-651) antibodyPIAS1 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 543-651) antibodyPIAS1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4A4 unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 422-651) antibodyPIAS1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 607-637), (C-Term) antibodyPIAS1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB00669 unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) antibodyPIAS1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) antibodyKD Validated PIAS1 适用: 人 WB 宿主: 兔 Monoclonal 25GB7815 unconjugated Recombinant Antibody
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 96-300) antibodyPIAS1 适用: 人 WB, ELISA, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 409-645) antibodyPIAS1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 1 (PIAS1) (AA 1-651) antibodyPIAS1 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse Immunocytochemistry , 0.5-1 μg/mL, Human, Mouse, Rat
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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: "The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion." in: JCI insight, Vol. 2, Issue 23, (2019) (PubMed).
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- PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))
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别名
- PIAS1
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背景
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Background: E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene. It is mapped to 15q23. This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. PIAS1 inhibited STAT1-mediated gene activation in response to interferon when expressed in mammalian cells. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. On the other hand, PIAS1 also can function as a SUMO ligase, or possibly as a tightly bound regulator of it, toward p53.
Gene Full Name: protein inhibitor of activated STAT 1
Sequence Similarities: Belongs to the PIAS family.
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分子量
- 100 kDa
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基因ID
- 8554
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UniProt
- O75925
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途径
- JAK/STAT Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C
抗原
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