PMVK 抗体 (Middle Region)
Quick Overview for PMVK 抗体 (Middle Region) (ABIN3044328)
抗原
See all PMVK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 135-151, Middle Region
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原理
- Anti-Phosphomevalonate kinase PMVK Antibody Picoband®
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序列
- EQSRQQRGWV FTPGVDD
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Phosphomevalonate kinase PMVK Antibody (ABIN3044328). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human PMVK, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
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亚型
- IgG
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anti-Phosphomevalonate Kinase (PMVK) (AA 1-192) antibody
PMVK 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2B8 unconjugated
anti-Phosphomevalonate Kinase (PMVK) (AA 1-192) antibodyPMVK 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Phosphomevalonate Kinase (PMVK) (AA 1-192) antibodyPMVK 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Phosphomevalonate Kinase (PMVK) antibodyPMVK 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 2D1 unconjugated
anti-Phosphomevalonate Kinase (PMVK) antibodyPMVK 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 1C12 unconjugated
anti-Phosphomevalonate Kinase (PMVK) (AA 15-120) antibodyPMVK 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Phosphomevalonate Kinase (PMVK) (AA 1-192) antibodyPMVK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Phosphomevalonate Kinase (PMVK) (Middle Region) antibodyPMVK 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Human, Mouse
Western blot, 0.1-0.5 μg/mL, Rat, Human, Mouse
1. Olivier, L. M., Chambliss, K. L., Gibson, K. M., Krisans, S. K. : Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. J. Lipid Res. 40: 672-679, 1999. 2. Chambliss, K. L., Slaughter, C. A., Schreiner, R., Hoffmann, G. F., Gibson, K. M. : Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence. J. Biol. Chem. 271: 17330-17334, 1996. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- PMVK (Phosphomevalonate Kinase (PMVK))
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别名
- PMVK
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背景
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Synonyms: Phosphomevalonate kinase,PMKase,hPMK,2.7.4.2,PMVK,PMKI,
Tissue Specificity: Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung. .
Background: PMVK (phosphomevalonate kinase) is a cytosolic enzyme that catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate. It is mapped to chromosome 1p13-1q22-23 and spans more than 8.4 kb in the human genome. PMVK is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, for localization to the organelle. It was expressed highly in heart, liver, skeletal muscle, kidney and pancreas and slightly lower in brain, placenta, and lung. And PMKase gene expression is subject to regulation by sterol at the level of transcription. It is a single copy gene covering less than 15 kb in the human genome. The human PMKase amino acid sequence contains a consensus peroxisomal targeting sequence (PTS-1), Ser-Arg-Leu, at the C terminus of the protein.
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分子量
- 77 kDa
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UniProt
- Q15126
抗原
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