Integrin alpha 1 抗体 (C-Term)
(1 reference)Quick Overview for Integrin alpha 1 抗体 (C-Term) (ABIN3044325)
抗原
See all Integrin alpha 1 (ITGA1) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1121-1134, C-Term
-
原理
- Anti-Integrin alpha 1/ITGA1 Antibody Picoband®
-
序列
- SNQKRELAIQ ISKD
-
交叉反应 （详细）
- No cross-reactivity with other proteins
-
产品特性
- Anti-Integrin alpha 1/ITGA1 Antibody (ABIN3044325). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha 1, different from the related mouse and rat sequences by one amino acid.
-
亚型
- IgG
-
-
anti-Integrin alpha 1 (ITGA1) (C-Term) antibody
ITGA1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha 1 (ITGA1) (AA 920-980) antibodyITGA1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha 1 (ITGA1) (AA 1-1179) antibodyITGA1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Integrin alpha 1 (ITGA1) (AA 103-368) antibodyITGA1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha 1 (ITGA1) (AA 951-1059) antibodyITGA1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4G11 unconjugated
anti-Integrin alpha 1 (ITGA1) antibody (PE)ITGA1 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal TS2-7 PE
anti-Integrin alpha 1 (ITGA1) (AA 1001-1179) antibodyITGA1 适用: 人, 大鼠 WB, ELISA, FACS, IF (p), IF (cc), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha 1 (ITGA1) (AA 125-366) antibodyITGA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha 1 (ITGA1) (AA 242-524) antibodyITGA1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha 1 (ITGA1) (AA 727-755) antibodyITGA1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB23364 unconjugated
-
-
应用备注
-
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Douville, P., Seldin, M. F., Carbonetto, S. : Genetic mapping of the integrin alpha-1 gene (Vla1) to mouse chromosome 13. Genomics 14: 503-505, 1992. 2. Lee HJ, Kim SY, Koh JM, Bok J, Kim KJ, Kim KS, Park MH, Shin HD, Park BL, Kim TH, Hong JM, Park EK, Kim DJ, Oh B, Kimm K, Kim GS, Lee JY. Polymorphisms and haplotypes of integrinalpha1 (ITGA1) are associated with bone mineral absorbance and fracture risk in postmenopausal Koreans.Bone. 2007 Dec,41(6):979-86. Epub 2007 Sep 5. 3. Ekholm, E., Hankenson, K. D., Uusitalo, H., Hiltunen, A., Gardner, H., Heino, J., Penttinen, R. : Diminished callus size and cartilage synthesis in alpha-1 beta-1 integrin-deficient mice during bone fracture healing. Am. J. Path. 160: 1779-1785, 2002. -
说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
-
-
-
: "A small physiological electric field mediated responses of extravillous trophoblasts derived from HTR8/SVneo cells: involvement of activation of focal adhesion kinase signaling." in: PLoS ONE, Vol. 9, Issue 3, pp. e92252, (2014) (PubMed).
-
: "A small physiological electric field mediated responses of extravillous trophoblasts derived from HTR8/SVneo cells: involvement of activation of focal adhesion kinase signaling." in: PLoS ONE, Vol. 9, Issue 3, pp. e92252, (2014) (PubMed).
-
- Integrin alpha 1 (ITGA1)
-
别名
- ITGA1
-
背景
-
Synonyms: Integrin alpha-1,CD49 antigen-like family member A,Laminin and collagen receptor,VLA-1,CD49a,ITGA1,
Tissue Specificity: Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. .
Background: Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.
Sequence Similarities: Belongs to the integrin alpha chain family.
-
分子量
- 190-200 kDa
-
UniProt
- P56199
-
途径
- EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex
抗原
-
