MMP24 抗体 (N-Term)
(2 references)Quick Overview for MMP24 抗体 (N-Term) (ABIN3044304)
抗原
See all MMP24 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 208-225, N-Term
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原理
- Anti-Matrix metalloproteinase-24 MMP24 Antibody Picoband®
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序列
- YHEIKSDRKE ADIMIFFA
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Matrix metalloproteinase-24 MMP24 Antibody (ABIN3044304). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human MMP24, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24) (AA 429-642) antibody
MMP24 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24) antibodyMMP24 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24) (AA 468-517) antibodyMMP24 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 犬, 斑马鱼, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24) (AA 396-425) antibodyMMP24 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2041-2042 unconjugated
anti-Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24) (Middle Region) antibodyMMP24 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Kinoh, H., Hayashita, H., Kajita, M., Okada, A., Seiki, M. Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2-q12, respectively, by radiation hybrid and in situ hybridization. Cytogenet. Cell Genet. 87: 97-98, 1999. 2. Llano, E., Pendas, A. M., Freije, J. P., Nakano, A., Knauper, V., Murphy, G., Lopez-Otin, C. Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase A overexpressed in brain tumors. Cancer Res. 59: 2570-2576, 1999. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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: "Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats." in: Molecular medicine reports, Vol. 16, Issue 6, pp. 8953-8963, (2018) (PubMed).
: "H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-β1 expression." in: Renal failure, Vol. 39, Issue 1, pp. 265-272, (2017) (PubMed).
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: "Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats." in: Molecular medicine reports, Vol. 16, Issue 6, pp. 8953-8963, (2018) (PubMed).
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- MMP24 (Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24))
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别名
- MMP24
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背景
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Synonyms: Matrix metalloproteinase-24,MMP-24,3.4.24.-,Membrane-type matrix metalloproteinase 5,MT-MMP 5,MTMMP5,Membrane-type-5 matrix metalloproteinase,MT5-MMP,MT5MMP,Processed matrix metalloproteinase-24,MMP24,MT5MMP,
Tissue Specificity: Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas. .
Background: Matrix metalloproteinase-24, also known as MT5MMP or MMP25, is an enzyme that in humans is encoded by the MMP24 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. This gene may be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans.
Sequence Similarities: Belongs to the peptidase M10A family.
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分子量
- 47 kDa
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UniProt
- Q9Y5R2
抗原
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