TACR1 抗体 (Middle Region)
Quick Overview for TACR1 抗体 (Middle Region) (ABIN3044262)
抗原
See all TACR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 231-245, Middle Region
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原理
- Anti-Neurokinin 1 Receptor/TACR1 Antibody Picoband®
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序列
- DSSDRYHEQV SAKRK
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Neurokinin 1 Receptor/TACR1 Antibody (ABIN3044262). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human TACR1, identical to the related rat and mouse sequences.
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亚型
- IgG
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anti-Tachykinin Receptor 1 (TACR1) (AA 2-50) antibody
TACR1 适用: 人, 大鼠 WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (C-Term) antibodyTACR1 适用: 人, 大鼠, 豚鼠, 猴, 马, 兔, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (Internal Region) antibodyVerified TACR1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (AA 180-194), (Extracellular) antibodyTACR1 适用: 大鼠 WB, IHC, FACS, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (AA 180-194), (Extracellular) antibody (Atto 488)KO Validated TACR1 适用: 大鼠 IHC, FACS, LCI 宿主: 兔 Polyclonal Atto 488
anti-Tachykinin Receptor 1 (TACR1) (AA 1-29) antibodyTACR1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (AA 140-243) antibodyTACR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (Extracellular Domain) antibodyTACR1 适用: 人, 犬, 猴, Cow IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) antibodyMicroarray verified TACR1 适用: 人 IHC 宿主: 小鼠 Monoclonal MAB139563 unconjugated
anti-Tachykinin Receptor 1 (TACR1) antibodyMicroarray verified TACR1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB323175 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Castagliuolo, I., Riegler, M., Pasha, A., Nikulasson, S., Lu, B., Gerard, C., Gerard, N. P., Pothoulakis, C.Neurokinin-1 (NK-1) receptor is required in Clostridium difficile-induced enteritis.J. Clin. Invest. 101: 1547-1550, 1998. 2. George, D. T., Gilman, J., Hersh, J., Thorsell, A., Herion, D., Geyer, C., Peng, X., Kielbasa, W., Rawlings, R., Brandt, J. E., Gehlert, D. R., Tauscher, J. T., Hunt, S. P., Hommer, D., Heilig, M.Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.Science 319: 1536-1539, 2008. 3. Lai, J.-P., Ho, W. Z., Kilpatrick, L. E., Wang, X., Tuluc, F., Korchak, H. M., Douglas, S. D.Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation.Proc. Nat. Acad. Sci. 103: 7771-7776, 2006. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- TACR1 (Tachykinin Receptor 1 (TACR1))
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别名
- TACR1
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背景
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Synonyms: Substance-P receptor,SPR,NK-1 receptor,NK-1R,Tachykinin receptor 1,TACR1,NK1R, TAC1R,
Tissue Specificity: Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. .
Background: The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
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分子量
- 55 kDa
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UniProt
- P25103
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途径
- Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration
抗原
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