电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

PRNP 抗体 (Middle Region)

PRNP 适用: 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3044180
发货至: 中国
  • 抗原 See all PRNP 抗体
    PRNP (Prion Protein (PRNP))
    抗原表位
    • 14
    • 14
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 143-159, Middle Region
    适用
    • 81
    • 32
    • 30
    • 10
    • 9
    • 3
    • 1
    • 1
    • 1
    大鼠, 小鼠
    宿主
    • 81
    • 15
    • 3
    • 1
    • 1
    克隆类型
    • 72
    • 29
    多克隆
    标记
    • 44
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This PRNP antibody is un-conjugated
    应用范围
    • 48
    • 31
    • 24
    • 24
    • 16
    • 15
    • 10
    • 7
    • 6
    • 6
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    原理
    Anti-Prion protein PrP/PRNP Antibody Picoband®
    序列
    DWEDRYYREN MYRYPNQ
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-Prion protein PrP/PRNP Antibody (ABIN3044180). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence in the middle region of mouse PRNP, identical to the related rat sequence.
    亚型
    IgG
    Top Product
    Discover our top product PRNP Primary Antibody
  • 应用备注
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Mouse
    Western blot, 0.1-0.5 μg/mL, Rat, Mouse
    1. Bounhar, Y., Zhang, Y., Goodyer, C. G., LeBlanc, A.Prion protein protects human neurons against Bax-mediated apoptosis.J. Biol. Chem. 276: 39145-39149, 2001. 2. Brown, P., Galvez, S., Goldfarb, L. G., Nieto, A., Cartier, L., Gibbs, C. J., Jr., Gajdusek, D. C.Familial Creutzfeldt-Jakob disease in Chile is associated with the codon 200 mutation of the PRNP amyloid precursor gene on chromosome 20.J. Neurol. Sci. 112: 65-67, 1992. 3. Puckett, C., Concannon, P., Casey, C., Hood, L.Genomic structure of the human prion protein gene.Am. J. Hum. Genet. 49: 320-329, 1991.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Thimerosal (Merthiolate), Sodium azide
    注意事项
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    PRNP (Prion Protein (PRNP))
    别名
    PRNP (PRNP 产品)
    背景

    Synonyms: Major prion protein,PrP,PrP27-30,PrP33-35C,CD230,Prnp,Prn-p, Prp,

    Tissue Specificity: Highly expressed in the brain, lung, kidney and heart. Expressed at low levels in the liver and spleen. .

    Background: PRNP (prion protein), also known as CD230 and PRP, is a protein that in humans is encoded by the PRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is most predominant in the nervous system but occurs in many other tissues throughout the body. Puckett et al. (1991)identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PRNP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. PRNP is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9-99.6 % similarity in amino acid sequences.

    分子量
    28 kDa
    UniProt
    P04925
    途径
    Transition Metal Ion Homeostasis, Activated T Cell Proliferation
You are here:
Chat with us!