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PRNP 抗体 (Middle Region)

This anti-PRNP antibody is a 兔 多克隆 antibody detecting PRNP in WB 和 IHC. Suitable for 大鼠 和 小鼠.
产品编号 ABIN3044180
发货至: 中国

Quick Overview for PRNP 抗体 (Middle Region) (ABIN3044180)

抗原

See all PRNP 抗体
PRNP (Prion Protein (PRNP))

适用

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大鼠, 小鼠

宿主

  • 90
  • 20
  • 3
  • 2
  • 1

克隆类型

  • 81
  • 35
多克隆

标记

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This PRNP antibody is un-conjugated

应用范围

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  • 35
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  • 7
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  • 3
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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

    • 15
    • 15
    • 8
    • 5
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    • 2
    • 2
    • 2
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    • 1
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    AA 143-159, Middle Region

    原理

    Anti-Prion protein PrP/PRNP Antibody Picoband®

    序列

    DWEDRYYREN MYRYPNQ

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-Prion protein PrP/PRNP Antibody (ABIN3044180). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence in the middle region of mouse PRNP, identical to the related rat sequence.

    亚型

    IgG
  • 应用备注

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Mouse
    Western blot, 0.1-0.5 μg/mL, Rat, Mouse
    1. Bounhar, Y., Zhang, Y., Goodyer, C. G., LeBlanc, A.Prion protein protects human neurons against Bax-mediated apoptosis.J. Biol. Chem. 276: 39145-39149, 2001. 2. Brown, P., Galvez, S., Goldfarb, L. G., Nieto, A., Cartier, L., Gibbs, C. J., Jr., Gajdusek, D. C.Familial Creutzfeldt-Jakob disease in Chile is associated with the codon 200 mutation of the PRNP amyloid precursor gene on chromosome 20.J. Neurol. Sci. 112: 65-67, 1992. 3. Puckett, C., Concannon, P., Casey, C., Hood, L.Genomic structure of the human prion protein gene.Am. J. Hum. Genet. 49: 320-329, 1991.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    储存液

    Thimerosal (Merthiolate), Sodium azide

    注意事项

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    PRNP (Prion Protein (PRNP))

    别名

    PRNP

    背景

    Synonyms: Major prion protein,PrP,PrP27-30,PrP33-35C,CD230,Prnp,Prn-p, Prp,

    Tissue Specificity: Highly expressed in the brain, lung, kidney and heart. Expressed at low levels in the liver and spleen. .

    Background: PRNP (prion protein), also known as CD230 and PRP, is a protein that in humans is encoded by the PRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is most predominant in the nervous system but occurs in many other tissues throughout the body. Puckett et al. (1991)identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PRNP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. PRNP is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9-99.6 % similarity in amino acid sequences.

    分子量

    28 kDa

    UniProt

    P04925

    途径

    Transition Metal Ion Homeostasis, Activated T Cell Proliferation
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