DPYD 抗体 (N-Term)
Quick Overview for DPYD 抗体 (N-Term) (ABIN3044151)
抗原
See all DPYD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 33-52, N-Term
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原理
- Anti-DPYD Antibody Picoband®
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序列
- AKKLDKKHWK RNPDKNCFNC
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-DPYD Antibody (ABIN3044151). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human DPYD, different from the related rat and mouse sequences by one amino acid.
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亚型
- IgG
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anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 1-110) antibody
DPYD 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 7D4 unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (Internal Region) antibodyDPYD 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (Internal Region) antibodyDPYD 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 1-173) antibodyDPYD 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) antibodyDPYD 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 841-875) antibodyDPYD 适用: 小鼠 WB 宿主: 兔 Polyclonal RB54986 unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 5-152) antibodyDPYD 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 169-422) antibodyDPYD 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidine Dehydrogenase (DPYD) (AA 33-52) antibodyDPYD 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Albin, N., Johnson, M. R., Shahinian, H., Wang, K., Diasio, R. B. Initial characterization of the molecular defect in human dihydropyrimidine dehydrogenase deficiency. Proc. Am. Assoc. Cancer Res. (Abstract) 36: 211 only, 1995. 2. McLeod, H. L., Collie-Duguid, E. S. R., Vreken, P., Johnson, M. R., Wei, X., Sapone, A., Diasio, R. B., Fernandez-Salguero, P., van Kuilenberg, A. B. P., van Gennip, A. H., Gonzales, F. J. Nomenclature for human DPYD alleles. Pharmacogenetics 8: 455-459, 1998. 3. Ridge, S. A., Brown, O., McMurrough, J., Fernandez-Salguero, P., Evans, W. E., Gonzalez, F. J., McLeod, H. L. Mutations at codon 974 of theDPYD gene are a rare event. Brit. J. Cancer 75: 178-179, 1997. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- DPYD (Dihydropyrimidine Dehydrogenase (DPYD))
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别名
- DPYD
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背景
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Synonyms: Dihydropyrimidine dehydrogenase [NADP (+)],DHPDHase,DPD,1.3.1.2,Dihydrothymine dehydrogenase,Dihydrouracil dehydrogenase,DPYD,
Tissue Specificity: Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
Background: DPYD (Dihydropyrimidine Dehydrogenase), also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the DPYD gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the DPYD gene is mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the DPYD gene is mapped to 1p22. The highest level of DPD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.
Sequence Similarities: Belongs to the dihydropyrimidine dehydrogenase family.
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分子量
- 11 kDa
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UniProt
- Q12882
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途径
- Ribonucleoside Biosynthetic Process
抗原
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