FER 抗体 (Middle Region)
Quick Overview for FER 抗体 (Middle Region) (ABIN3044101)
抗原
See all FER 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 521-536, Middle Region
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原理
- Anti-Tyrosine-protein kinase Fer FER Antibody Picoband®
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序列
- FSNIPQLIDH HYTTKQ
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Tyrosine-protein kinase Fer FER Antibody (ABIN3044101). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human FER, different from the related rat and mouse sequences by two amino acids.
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亚型
- IgG
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anti-FER Tyrosine Kinase (FER) antibody
FER 适用: 人, 小鼠 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 5D2C4 unconjugated
anti-FER Tyrosine Kinase (FER) (AA 1-300) antibodyFER 适用: 人, 小鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 1457CT181-12-17 unconjugated
anti-FER Tyrosine Kinase (FER) antibodyFER 适用: 小鼠 WB, IF, FACS 宿主: 小鼠 Monoclonal 1487CT794-8-50 unconjugated
anti-FER Tyrosine Kinase (FER) (AA 782-811), (C-Term) antibodyFER 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB03222 unconjugated
anti-FER Tyrosine Kinase (FER) antibodyFER 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FER Tyrosine Kinase (FER) (Ser376) antibodyFER 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-FER Tyrosine Kinase (FER) (C-Term) antibodyFER 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-FER Tyrosine Kinase (FER) (C-Term) antibodyFER 适用: 人, 犬, Cow, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-FER Tyrosine Kinase (FER) (C-Term) antibodyFER 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-FER Tyrosine Kinase (FER) (C-Term) antibodyFER 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Arregui, C., Pathre, P., Lilien, J., Balsamo, J. The nonreceptor tyrosine kinase Fer mediates cross-talk between N-cadherin and beta-1-integrins. J. Cell Biol. 149: 1263-1273, 2000. 2. McCafferty, D.-M., Craig, A. W. B., Senis, Y. A., Greer, P. A. Absence of Fer protein-tyrosine kinase exacerbates leukocyte recruitment in response to endotoxin. J. Immun. 168: 4930-4935, 2002. 3. Morris, C., Heisterkamp, N., Hao, Q. L., Testa, J. R., Groffen, J. The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q). Cytogenet. Cell Genet. 53: 196-200, 1990. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- FER (FER Tyrosine Kinase (FER))
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别名
- FER
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背景
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Synonyms: Tyrosine-protein kinase Fer,2.7.10.2,Feline encephalitis virus-related kinase FER,Fujinami poultry sarcoma/Feline sarcoma-related protein Fer,Proto-oncogene c-Fer,Tyrosine kinase 3,p94-Fer,FER,TYK3,
Tissue Specificity: Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed. .
Background: FER (FPS/FES-Related tyrosine kinase) also known as TYK3, is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al. (1990) concluded that the FER gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that FER mediates crosstalk between CDH2 and ITGB1. In Fer mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that FER has a role in regulating innate immunity.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
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分子量
- 95 kDa
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UniProt
- P16591
抗原
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