CUEDC2 抗体 (C-Term)
Quick Overview for CUEDC2 抗体 (C-Term) (ABIN3044031)
抗原
See all CUEDC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 267-287, C-Term
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原理
- Anti-CUEDC2 Antibody Picoband®
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序列
- EAEEMKATYI NLKPARKYRF H
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-CUEDC2 Antibody (ABIN3044031). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human CUEDC2, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
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亚型
- IgG
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anti-CUE Domain Containing 2 (CUEDC2) (AA 201-287) antibody
CUEDC2 适用: 小鼠 ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-CUE Domain Containing 2 (CUEDC2) antibodyCUEDC2 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CUE Domain Containing 2 (CUEDC2) (AA 1-226) antibodyCUEDC2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-CUE Domain Containing 2 (CUEDC2) (C-Term) antibodyCUEDC2 适用: 人 WB, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-CUE Domain Containing 2 (CUEDC2) (AA 239-267), (C-Term) antibodyCUEDC2 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB19592 unconjugated
anti-CUE Domain Containing 2 (CUEDC2) (AA 239-267) antibodyCUEDC2 适用: 人 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
anti-CUE Domain Containing 2 (CUEDC2) (AA 250-300) antibodyCUEDC2 适用: 人, 小鼠, Cow, 马, 犬, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-CUE Domain Containing 2 (CUEDC2) (AA 50-100) antibodyCUEDC2 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CUE Domain Containing 2 (CUEDC2) (AA 1-150) antibodyCUEDC2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CUE Domain Containing 2 (CUEDC2) (C-Term) antibodyCUEDC2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Hartz, P. A. Personal Communication. Baltimore, Md. 7/26/2011. 2. Pan, X., Zhou, T., Tai, Y.-H., Wang, C., Zhao, J., Cao, Y., Chen, Y., Zhang, P.-J., Yu, M., Zhen, C., Mu, R., Bai, Z.-F., and 10 others. Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. Nature Med. 17: 708-714, 2011. 3. Zhang, P.-J., Zhao, J., Li, H.-Y., Man, J.-H., He, K., Zhou, T., Pan, X., Li, A.-L., Gong, W.-L., Jin, B.-F., Xia, Q., Yu, M., Shen, B.-F., Zhang, X.-M. CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. EMBO J. 26: 1831-1842, 2007. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- CUEDC2 (CUE Domain Containing 2 (CUEDC2))
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别名
- CUEDC2
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背景
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Synonyms: CUE domain-containing protein 2,CUEDC2,C10orf66,HOYS6,
Tissue Specificity: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.
Background: CUEDC2 (Cue Domain-Containing Protein 2) is involved in ubiquitin-and proteasome-mediated degradation of progesterone receptor (PR, or PGR) and estrogen receptor (ER)-alpha. Hartz (2011) mapped the CUEDC2 gene to chromosome 10q24.32 based on an alignment of the CUEDC2 sequence with the genomic sequence (GRCh37). Using coimmunoprecipitation analysis and protein pull-down assays, Zhang et al. (2007) confirmed that CUEDC2 interacted with the PRB isoform of PR. Mutation analysis revealed that the IF domain of PRB and the CUE domain of CUEDC2 were required for the interaction. CUEDC2 reduced PRB protein content and promoted progesterone-induced PRB degradation via the ubiquitin-proteasome pathway.
Sequence Similarities: Belongs to the CUEDC2 family.
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分子量
- 32 kDa, 19 kDa
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UniProt
- Q9H467
抗原
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