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EGR1 抗体 (N-Term)

EGR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3043997
发货至: 中国
  • 抗原 See all EGR1 抗体
    EGR1 (Early Growth Response 1 (EGR1))
    抗原表位
    • 15
    • 9
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 23-43, N-Term
    适用
    • 58
    • 37
    • 23
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 1
    宿主
    • 50
    • 10
    • 1
    克隆类型
    • 48
    • 13
    多克隆
    标记
    • 37
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EGR1 antibody is un-conjugated
    应用范围
    • 49
    • 25
    • 17
    • 12
    • 12
    • 12
    • 8
    • 6
    • 5
    • 5
    • 4
    • 1
    • 1
    Western Blotting (WB)
    原理
    Anti-Egr1 Antibody Picoband®
    序列
    FPHSPTMDNY PKLEEMMLLS N
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-Egr1 Antibody (ABIN3043997). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the N-terminus of human Egr1, identical to the related rat and mouse sequences.
    亚型
    IgG
    Top Product
    Discover our top product EGR1 Primary Antibody
  • 应用备注
    Western blot, 0.1-0.5 μg/mL, Human
    1. Das, A., Chendil, D., Dey, S., Mohiuddin, M., Mohiuddin, M., Milbrandt, J., Rangnekar, V. M., Ahmed, M. M. Ionizing radiation down-regulates p53 protein in primary Egr-1(-/-) mouse embryonic fibroblast cells causing enhanced resistance to apoptosis. J. Biol. Chem. 276: 3279-3286, 2001. 2. Joslin, J. M., Fernald, A. A., Tennant, T. R., Davis, E. M., Kogan, S. C., Anastasi, J., Crispino, J. D., Le Beau, M. M. Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood 110: 719-726, 2007.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • Lin, Fang, Cai, Huang, Zhang, Lu, Zhang, Wei: "ERK/Egr-1 signaling pathway is involved in CysLT2 receptor-mediated IL-8 production in HEK293 cells." in: European journal of cell biology, Vol. 93, Issue 7, pp. 278-88, (2014) (PubMed).

  • 抗原
    EGR1 (Early Growth Response 1 (EGR1))
    别名
    EGR1 (EGR1 产品)
    背景

    Synonyms: Early growth response protein 1,EGR-1,AT225,Nerve growth factor-induced protein A,NGFI-A,Transcription factor ETR103,Transcription factor Zif268,Zinc finger protein 225,Zinc finger protein Krox-24,EGR1,KROX24, ZNF225,

    Tissue Specificity: In eosinophils as well as trace amounts in neutrophils and monocytes.

    Background: Earlu growth response protein 1, also known as ZIF268 or NGFIA, is a protein that in humans is encoded by the EGR1 gene. The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. This gene is mapped to 5q31.2. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. It has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity.

    Sequence Similarities: Belongs to the EGR C2H2-type zinc-finger protein family.

    分子量
    58 kDa
    UniProt
    P18146
    途径
    Regulation of Carbohydrate Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity
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