Vitamin D Receptor 抗体 (C-Term)
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- 抗原 See all Vitamin D Receptor (VDR) 抗体
- Vitamin D Receptor (VDR)
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抗原表位
- AA 377-402, C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Vitamin D Receptor antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- Anti-Vitamin D Receptor/VDR Antibody Picoband®
- 序列
- HLLYAKMIQK LADLRSLNEE HSKQYR
- 交叉反应 （详细）
- No cross-reactivity with other proteins
- 产品特性
- Anti-Vitamin D Receptor/VDR Antibody Picoband® (ABIN3043960). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human VDR, different from the related mouse and rat sequences by one amino acid.
- 亚型
- IgG
- Top Product
- Discover our top product VDR Primary Antibody
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anti-Vitamin D Receptor (VDR) (AA 65-180) antibody
VDR 适用: 人, 小鼠, 大鼠 WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (AA 1-427) antibodyVDR 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (N-Term) antibodyVDR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (pSer208) antibodyVDR 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (AA 266-422) antibodyVDR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) antibodyVDR 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 3C7 unconjugated Recombinant Antibody
anti-Vitamin D Receptor (VDR) (AA 1-428) antibodyVDR 适用: 人 ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2F4 unconjugated
anti-Vitamin D Receptor (VDR) (AA 1-427) antibodyVDR 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F4 unconjugated
anti-Vitamin D Receptor (VDR) (AA 274-299) antibodyVDR 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Vitamin D Receptor (VDR) (pSer51) antibodyVDR 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Jurutka, P. W., Remus, L. S., Whitfield, G. K., Thompson, P. D., Hsieh, J.-C., Zitzer, H., Tavakkoli, P., Galligan, M. A., Dang, H. T. L., Haussler, C. A., Haussler, M. R. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Molec. Endocr. 14: 401-420, 2000. 2. Labuda, M., Ross, M. V., Fujiwara, T. M., Morgan, K., Ledbetter, D., Hughes, M. R., Glorieux, F. H. Two hereditary defects related to vitamin D metabolism map to the same region of human chromosome 12q.II(Abstract) Cytogenet. Cell Genet. 58: 1978, 1991. 3. Shah, S., Islam, M. N., Dakshanamurthy, S., Rizvi, I., Rao, M., Herrell, R., Zinser, G., Valrance, M., Aranda, A., Moras, D., Norman, A., Welsh, J., Byers, S. W. The molecular basis of vitamin D receptor and beta-catenin crossregulation. Molec. Cell 21: 799-809, 2006. Note: Erratum: Molec. Cell 21: 148 only, 2006. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR." in: American journal of translational research, Vol. 9, Issue 11, pp. 4963-4973, (2017) (PubMed).
: "Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats." in: PLoS ONE, Vol. 11, Issue 3, pp. e0151118, (2016) (PubMed).
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: "MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR." in: American journal of translational research, Vol. 9, Issue 11, pp. 4963-4973, (2017) (PubMed).
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- 抗原
- Vitamin D Receptor (VDR)
- 别名
- VDR (VDR 产品)
- 物质类
- Chemical
- 背景
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Synonyms: Vitamin D3 receptor,VDR,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1,VDR,NR1I1,
Tissue Specificity: Heart, liver and skeletal muscle.
Background: VDR (Vitamin D Receptor), also known as Vitamin D Hormone Receptor, is a member of the nuclear receptor family of transcription factors. Labuda et al. (1991) assigned the VDR gene to 12q12-q14 by in situ hybridization. Using mutation analysis, Jurutka et al. (2000) characterized arg18/arg22, VDR residues immediately N-terminal of the first DNA-binding zinc finger, as vital for contact with the general transcription factor IIB (TFIIB). A natural polymorphic variant of VDR, termed F/M4 (missing a FokI restriction site), which lacks only the first 3 amino acids (including glu2), interacted more efficiently with TFIIB and also possessed elevated transcriptional activity compared with the full-length (f/M1) receptor. Shah et al. (2006) stated that the signaling and oncogenic activity of beta-catenin (CTNNB1) can be repressed by activation of VDR. Conversely, high levels of beta-catenin can potentiate the transcriptional activity of 1,25- dihydroxyvitamin D3.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.
- 分子量
- 48 kDa
- 基因ID
- 7421
- UniProt
- P11473
- 途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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