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Vitamin D Receptor 抗体 (C-Term)

Name: Vitamin D Receptor 抗体 (C-Term)
SKU: ABIN3043960
Availability: OutOfStock

This anti-Vitamin D Receptor antibody is a 兔多克隆 antibody detecting Vitamin D Receptor in WB 和 IHC. Suitable for 人, 小鼠和大鼠. This Primary Antibody has been cited in 2+ publications.

Anti-VDR Picoband antibody, Western blotting All lanes: Anti VDR at 0. (Vitamin D Receptor 抗体 (C-Term))

Anti-VDR Picoband antibody, IHC(P) IHC(P): Mouse Intestine Tissue (Vitamin D Receptor 抗体 (C-Term))

IHC

Anti-VDR Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue (Vitamin D Receptor 抗体 (C-Term))

IHC

Anti-VDR Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue (Vitamin D Receptor 抗体 (C-Term))

IHC

4 images

(2 references)

产品编号 ABIN3043960

发货至: 中国

Quick Overview for Vitamin D Receptor 抗体 (C-Term) (ABIN3043960)

抗原

See all Vitamin D Receptor (VDR) 抗体

Vitamin D Receptor (VDR)

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This Vitamin D Receptor antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product VDR Primary Antibody

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AA 377-402, C-Term

原理

Anti-Vitamin D Receptor/VDR Antibody Picoband®

序列

HLLYAKMIQK LADLRSLNEE HSKQYR

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Vitamin D Receptor/VDR Antibody Picoband® (ABIN3043960). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human VDR, different from the related mouse and rat sequences by one amino acid.

亚型

IgG
anti-Vitamin D Receptor (VDR) (AA 65-180) antibody
VDR 适用: 人, 小鼠, 大鼠 WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Vitamin D Receptor (VDR) (AA 1-427) antibody
VDR 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Vitamin D Receptor (VDR) (AA 1-300) antibody
VDR 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Vitamin D Receptor (VDR) (N-Term) antibody
VDR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Vitamin D Receptor (VDR) (pSer208) antibody
VDR 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Vitamin D Receptor (VDR) (AA 266-422) antibody
VDR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Vitamin D Receptor (VDR) antibody
VDR 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 3C7 unconjugated Recombinant Antibody

anti-Vitamin D Receptor (VDR) (AA 1-428) antibody
VDR 适用: 人 ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2F4 unconjugated

anti-Vitamin D Receptor (VDR) (AA 1-427) antibody
VDR 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F4 unconjugated

anti-Vitamin D Receptor (VDR) (AA 181-230) antibody
VDR 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Jurutka, P. W., Remus, L. S., Whitfield, G. K., Thompson, P. D., Hsieh, J.-C., Zitzer, H., Tavakkoli, P., Galligan, M. A., Dang, H. T. L., Haussler, C. A., Haussler, M. R. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Molec. Endocr. 14: 401-420, 2000. 2. Labuda, M., Ross, M. V., Fujiwara, T. M., Morgan, K., Ledbetter, D., Hughes, M. R., Glorieux, F. H. Two hereditary defects related to vitamin D metabolism map to the same region of human chromosome 12q.II(Abstract) Cytogenet. Cell Genet. 58: 1978, 1991. 3. Shah, S., Islam, M. N., Dakshanamurthy, S., Rizvi, I., Rao, M., Herrell, R., Zinser, G., Valrance, M., Aranda, A., Moras, D., Norman, A., Welsh, J., Byers, S. W. The molecular basis of vitamin D receptor and beta-catenin crossregulation. Molec. Cell 21: 799-809, 2006. Note: Erratum: Molec. Cell 21: 148 only, 2006.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Hou, Huang, Luo, Wang, Liu, Deng, Zhang, Liu, Chen: "MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR." in: American journal of translational research, Vol. 9, Issue 11, pp. 4963-4973, (2017) (PubMed).

Gao, Wang, Yan, Zeng, Ma, Niu, Zhou, Jiang, Chen: "Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats." in: PLoS ONE, Vol. 11, Issue 3, pp. e0151118, (2016) (PubMed).
抗原

Vitamin D Receptor (VDR)

别名

VDR

物质类

Chemical

背景

Synonyms: Vitamin D3 receptor,VDR,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1,VDR,NR1I1,
Tissue Specificity: Heart, liver and skeletal muscle.
Background: VDR (Vitamin D Receptor), also known as Vitamin D Hormone Receptor, is a member of the nuclear receptor family of transcription factors. Labuda et al. (1991) assigned the VDR gene to 12q12-q14 by in situ hybridization. Using mutation analysis, Jurutka et al. (2000) characterized arg18/arg22, VDR residues immediately N-terminal of the first DNA-binding zinc finger, as vital for contact with the general transcription factor IIB (TFIIB). A natural polymorphic variant of VDR, termed F/M4 (missing a FokI restriction site), which lacks only the first 3 amino acids (including glu2), interacted more efficiently with TFIIB and also possessed elevated transcriptional activity compared with the full-length (f/M1) receptor. Shah et al. (2006) stated that the signaling and oncogenic activity of beta-catenin (CTNNB1) can be repressed by activation of VDR. Conversely, high levels of beta-catenin can potentiate the transcriptional activity of 1,25- dihydroxyvitamin D3.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.

分子量

48 kDa

基因ID

7421

UniProt

P11473

途径

Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway