MMP8 抗体 (N-Term)
(3 references)Our Local Distributor
北京 101111
Quick Overview for MMP8 抗体 (N-Term) (ABIN3043883)
抗原
See all MMP8 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 120-157, N-Term
-
原理
- Anti-MMP8 Antibody
-
序列
- HTPQLSRAEV KTAIEKAFHV WSVASPLTFT EILQGEAD
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-MMP8 Antibody (ABIN3043883). Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of mouse MMP-8, different from the related human sequence by eleven amino acids, and from the related rat sequence by nine amino acids.
-
亚型
- IgG
-
-
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 101-467) antibody
MMP8 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C8 unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) antibodyMMP8 适用: 人 WB, IP, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) antibodyMMP8 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 241-340) antibodyMMP8 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 101-467) antibodyMMP8 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 22-283) antibodyMMP8 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (C-Term) antibodyMMP8 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 1-467) antibodyMMP8 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 1-467) antibodyMMP8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) (AA 119-153), (N-Term) antibodyMMP8 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
Western blot, 0.1-0.5 μg/mL, Mouse, Rat
-
说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
-
: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).
: "Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats." in: Frontiers in pharmacology, Vol. 6, pp. 215, (2015) (PubMed).
: "Expression of matrix metalloproteinases-8 and -9 and their tissue inhibitor in the condyles of diabetic rats with mandibular advancement." in: Experimental and therapeutic medicine, Vol. 8, Issue 5, pp. 1357-1364, (2014) (PubMed).
-
: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).
-
- MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))
-
别名
- Mmp8
-
背景
-
Synonyms: Neutrophil collagenase,3.4.24.34,Collagenase 2,Matrix metalloproteinase-8,MMP-8,Mmp8,
Tissue Specificity: Neutrophils. Expressed in uterus. Low levels in kidney and muscle.
Background: MMP8 (Matrix metalloproteinase 8) is a member of the family of matrix metalloproteinases. It is distinct from the collagenase of skin fibroblasts and synovial cells in substrate specificity and immunologic crossreactivity. MMP8 is mapped to 11q21-q22. MMP8 is an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. The enzyme exhibits 58 % homology to human fibroblast collagenase and has the same domain structure. It consists of a 20-residue signal peptide, and an 80-residue propeptide that is lost on autolytic activation by cleavage of an M-L bond. MMP8 was found to possess 57 % identity with the deduced protein sequence for fibroblast collagenase with 72 % chemical similarity. Matrix metalloproteinases (MMPs) have fundamental roles in tumor progression, but most clinical trials with MMP inhibitors have not shown improvements in individuals with cancer. MMP8 has a paradoxical protective role in cancer and provides a genetic model to evaluate the molecular basis of gender differences in cancer susceptibility.
-
分子量
- 55 kDa
-
基因ID
- 17394
-
UniProt
- O70138
抗原
-
