HSP70 1A 抗体 (C-Term)
(13 references)Quick Overview for HSP70 1A 抗体 (C-Term) (ABIN3043849)
抗原
See all HSP70 1A (HSPA1A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 559-596, C-Term
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原理
- Anti-Hsp70/HSPA1A/HSPA1B Antibody
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序列
- KGKISEADKK KVLDKCQEVI SWLDANTLAE KDEFEHKR
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Hsp70/HSPA1A/HSPA1B Antibody (ABIN3043849). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Hsp70, different from the related mouse sequence by five amino acids, and from the related rat sequence by three amino acids.
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亚型
- IgG
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anti-Heat Shock 70kDa Protein 1A (HSPA1A) (Center) antibody
HSPA1A 适用: 人, 小鼠, 大鼠 WB, IP, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 1A (HSPA1A) (AA 285-641) antibodyHSPA1A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 1A (HSPA1A) (AA 1-641) antibodyHSPA1A 适用: 人 WB, IHC, IP, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 1A (HSPA1A) antibodyHSPA1A 适用: 人, 犬, 猴 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3C6 unconjugated
anti-Heat Shock 70kDa Protein 1A (HSPA1A) (AA 500-600) antibodyHSPA1A 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 1A (HSPA1A) (AA 285-641) antibodyHSPA1A 适用: 人 WB 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Heat Shock 70kDa Protein 1A (HSPA1A) (C-Term) antibodyHSPA1A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 1A (HSPA1A) (AA 1-641) antibodyHSPA1A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 1A (HSPA1A) (AA 1-641) antibodyHSPA1A 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal 2# unconjugated
anti-Heat Shock 70kDa Protein 1A (HSPA1A) (AA 418-512) antibodyHSPA1A 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 8985623, (2017) (PubMed).
: "Effects of intracerebral hemorrhage and subsequent minimally invasive hematoma aspiration on expression of apoptosisrelated genes in rats." in: International journal of clinical and experimental pathology, Vol. 8, Issue 5, pp. 5371-8, (2016) (PubMed).
: "Study on the immune response to recombinant Hsp70 protein from Megalobrama amblycephala." in: Immunobiology, Vol. 219, Issue 11, pp. 850-8, (2014) (PubMed).
: "Acute effect of copper and cadmium exposure on the expression of heat shock protein 70 in the Cyprinidae fish Tanichthys albonubes." in: Chemosphere, Vol. 91, Issue 8, pp. 1113-22, (2013) (PubMed).
: "Effects of minocycline on the expression of NGF and HSP70 and its neuroprotection role following intracerebral hemorrhage in rats." in: Journal of biomedical research, Vol. 25, Issue 4, pp. 292-8, (2013) (PubMed).
: "Severe multiple organ injury in HSF1 knockout mice induced by lipopolysaccharide is associated with an increase in neutrophil infiltration and surface expression of adhesion molecules." in: Journal of leukocyte biology, Vol. 92, Issue 4, pp. 851-7, (2012) (PubMed).
: "Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system." in: Molecular vision, Vol. 18, pp. 317-29, (2012) (PubMed).
: "Effects of adrenergic agents on stress-induced brain microstructural and immunochemical changes in adult male Wistar rats." in: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, Vol. 193, Issue 5, pp. 418-24, (2011) (PubMed).
: "Immunohistological evaluation of skin responses after treatment using a fractional ultrapulse carbon dioxide laser on back skin." in: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], Vol. 37, Issue 8, pp. 1141-9, (2011) (PubMed).
: "Thermoseed hyperthermia treatment of mammary orthotopic transplantation tumors in rats and impact on immune function." in: Oncology reports, Vol. 24, Issue 4, pp. 973-9, (2010) (PubMed).
: "Effect of pre-moxibustion on apoptosis and proliferation of gastric mucosa cells." in: World journal of gastroenterology, Vol. 13, Issue 15, pp. 2174-8, (2007) (PubMed).
: "Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells." in: World journal of gastroenterology, Vol. 10, Issue 20, pp. 2944-8, (2004) (PubMed).
: "[Homo- and autotransplantation of bone marrow in radiation and chemotherapy of oncologic patients]." in: Vrachebnoe delo, Vol. 4, pp. 129-32, (1973) (PubMed).
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: "Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 8985623, (2017) (PubMed).
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- HSP70 1A (HSPA1A) (Heat Shock 70kDa Protein 1A (HSPA1A))
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别名
- HSPA1A
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背景
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Synonyms: Heat shock 70 kDa protein 1A ,Heat shock 70 kDa protein 1,HSP70-1 ,HSP70.1,HSPA1A,HSPA1, HSX70,
Tissue Specificity: Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues. .
Background: HSPA1 (heat shock 70 kDa protein 1A) also known as HSP70-1, HSPA1A, HSP70-1A, HSP72 or HSP70I, is a protein that in humans is encoded by the HSPA1A gene. This intronless gene encodes a 70 kDa heat shock protein which is a member of the heat shock protein 70 family. The HSPA1A gene encodes a predicted 641-amino acid protein. The HSPA1 gene is mapped on 6p21.33. Shimizu et al. (1999) found that peripheral blood mononuclear cells of 18 major depression patients expressed a short HSPA1A transcript that utilized exon 1 rather than exon 2, which is found in the more common HSPA1A transcript. No protein was associated with expression of this short HSPA1A mRNA, possibly due to lack of a TATA box or loss of internal ribosome binding sites. Treatment with BGP-15, a pharmacologic inducer of Hsp72 that can protect against obesity-induced insulin resistance, improved muscular architecture, strength, and contractile function in severely affected diaphragm muscles in mdx dystrophic mice.
Sequence Similarities: Contains 1 HMG box DNA-binding domain.
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分子量
- 70 kDa
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基因ID
- 3303, 3304
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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