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GFAP 抗体 (AA 93-432)

This anti-GFAP antibody is a 兔 多克隆 antibody detecting GFAP in WB, IHC 和 IF. Suitable for 人, 大鼠 和 小鼠. This Primary Antibody has been cited in 83+ publications.
Pubmed (83 references)
产品编号 ABIN3043832
发货至: 中国

Quick Overview for GFAP 抗体 (AA 93-432) (ABIN3043832)

抗原

See all GFAP 抗体
GFAP (Glial Fibrillary Acidic Protein (GFAP))

适用

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人, 大鼠, 小鼠

宿主

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兔

克隆类型

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多克隆

标记

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This GFAP antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Discover our top product GFAP Primary Antibody

  • 抗原表位

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    AA 93-432

    原理

    Anti-GFAP Antibody Picoband®

    交叉反应 （详细）

    No cross-reactivity with other proteins

    产品特性

    Anti-GFAP Antibody Picoband® (ABIN3043832). Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat, Pig. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human GFAP recombinant protein (Position: Q93-M432). Human GFAP shares 94% amino acid (aa) sequence identity with both mouse and rat GFAP.

    亚型

    IgG
  • anti-Glial Fibrillary Acidic Protein (GFAP) (AA 51-150) antibody
    anti-Glial Fibrillary Acidic Protein (GFAP) (AA 51-150) antibody

    GFAP 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, FACS, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated

    anti-Glial Fibrillary Acidic Protein (GFAP) (C-Term) antibody
    anti-Glial Fibrillary Acidic Protein (GFAP) (C-Term) antibody

    GFAP 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

    anti-Glial Fibrillary Acidic Protein (GFAP) (AA 253-354) antibody
    anti-Glial Fibrillary Acidic Protein (GFAP) (AA 253-354) antibody

    GFAP 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

    anti-Glial Fibrillary Acidic Protein (GFAP) (AA 1-430) antibody
    anti-Glial Fibrillary Acidic Protein (GFAP) (AA 1-430) antibody

    GFAP 适用: 大鼠 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C1 unconjugated

    anti-Glial Fibrillary Acidic Protein (GFAP) (AA 292-432) antibody
    anti-Glial Fibrillary Acidic Protein (GFAP) (AA 292-432) antibody

    GFAP 适用: 人 WB, IHC, IF, ELISA, FACS 宿主: 小鼠 Monoclonal 1C91F1 unconjugated

    anti-Glial Fibrillary Acidic Protein (GFAP) (pSer38) antibody
    anti-Glial Fibrillary Acidic Protein (GFAP) (pSer38) antibody

    GFAP 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

    anti-Glial Fibrillary Acidic Protein (GFAP) (C-Term) antibody
    anti-Glial Fibrillary Acidic Protein (GFAP) (C-Term) antibody

    Verified GFAP 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

    anti-Glial Fibrillary Acidic Protein (GFAP) antibody
    anti-Glial Fibrillary Acidic Protein (GFAP) antibody

    GFAP 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated

    anti-Glial Fibrillary Acidic Protein (GFAP) (AA 108-211) antibody
    anti-Glial Fibrillary Acidic Protein (GFAP) (AA 108-211) antibody

    GFAP 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

    anti-Glial Fibrillary Acidic Protein (GFAP) antibody
    anti-Glial Fibrillary Acidic Protein (GFAP) antibody

    GFAP 适用: 人, 大鼠, 小鼠, Pig, Cow, 小鸡, 兔 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal GA-5 unconjugated

  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat, Pig
    Immunofluorescence, 5 μg/mL, Rat1. Eng LF, Ghirnikar RS, Lee YL (October 2000). "Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)". Neurochem. Res. 25 (9-10): 1439-51. 2. Tardy M, Fages C, Le Prince G, Rolland B, Nunez J (1990). "Regulation of the glial fibrillary acidic protein (GFAP) and of its encoding mRNA in the developing brain and in cultured astrocytes". Adv. Exp. Med. Biol. 265: 41-52. 3. Weinstein DE, Shelanski ML, Liem RK (1991). "Suppression by antisense mRNA demonstrates a requirement for the glial fibrillary acidic protein in the formation of stable astrocytic processes in response to neurons". The Journal of Cell Biology 112 (6): 1205-1213.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用

  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Lyukmanova, Kirichenko, Medyanik, Yashin, Kirpichnikov, Bychkov: "Extracellular Vesicles from Plasma of Patients with Glioblastoma Promote Invasion of Glioblastoma Cells Even After Tumor Resection." in: Biomedicines, Vol. 12, Issue 12, (2024) (PubMed).

    Liu, Mei, Li, Roboti, Pang, Ying, Gao, Lowe, Bao: "Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 2, pp. 346-351, (2018) (PubMed).

    Xu, Hu, Jiang, Pan, Shen, Schachner: "Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice." in: Disease models & mechanisms, Vol. 10, Issue 9, pp. 1117-1128, (2018) (PubMed).

    Liu, Zhao, Ji, Zhu, Sui, Knight, Burnstock, He, Yuan, Xiang: "Inhibition of P2X7 receptors improves outcomes after traumatic brain injury in rats." in: Purinergic signalling, Vol. 13, Issue 4, pp. 529-544, (2018) (PubMed).

    Ding, Yao, Hong, Li, Zhu, Han, Zhou: "The analgesic effect of early hyperbaric oxygen treatment in chronic constriction injury rats and its influence on nNOS and iNOS expression and inflammatory factor production." in: Molecular pain, Vol. 14, pp. 1744806918765840, (2018) (PubMed).

    Daugherty, Chechneva, Mayrhofer, Deng: "The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis." in: Scientific reports, Vol. 6, pp. 22556, (2017) (PubMed).

    Mi, Gao, Liu, Ye, Li, Jin, Yang, Yang: "Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model." in: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 20, pp. 2780-91, (2017) (PubMed).

    Zhai, Zhao, Zhou, Lu, Zhang, Na, Feng, Qiang, Du: "The association and significance of H3K27me3 and a folate metabolic gene ACat2 in neural tube defects." in: Nutrition journal, Vol. 15, Issue 1, pp. 95, (2017) (PubMed).

    Xu, Lu, Miao, Wu, -Z Jiang, Ge, Fang, Zhu, Chen, Zhou, Lu, Tang, Wang: "Immunoregulatory effect of neuronal-like cells in inducting differentiation of bone marrow mesenchymal stem cells." in: European review for medical and pharmacological sciences, Vol. 20, Issue 24, pp. 5041-5048, (2017) (PubMed).

    Yang, Xie, Hu, Jiang, Shen, Schachner, Zhao: "CHL1 Is Expressed and Functions as a Malignancy Promoter in Glioma Cells." in: Frontiers in molecular neuroscience, Vol. 10, pp. 324, (2017) (PubMed).

    Jiang, Luo, Qin, Ma, Li, Zhan, Zhang: "Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats." in: Frontiers in molecular neuroscience, Vol. 10, pp. 363, (2017) (PubMed).

    Wang, Lin, Cao, Duan, Guan, Xu, Zhu, Xia: "Up-regulation of Interleukin-21 Contributes to Liver Pathology of Schistosomiasis by Driving GC Immune Responses and Activating HSCs in Mice." in: Scientific reports, Vol. 7, Issue 1, pp. 16682, (2017) (PubMed).

    Tang, Luo, Qiu, Zhang, Lu, Huang, Xu, Xu: "Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy." in: Scientific reports, Vol. 7, Issue 1, pp. 18110, (2017) (PubMed).

    Yuan, Hu, Gao: "Brain Localization and Neurotoxicity Evaluation of Polysorbate 80-Modified Chitosan Nanoparticles in Rats." in: PLoS ONE, Vol. 10, Issue 8, pp. e0134722, (2016) (PubMed).

    Cui, Li, Gai, She, Zhang, Xu, Chen, An, Ma, Wang: "Chronic Noise Exposure Acts Cumulatively to Exacerbate Alzheimer's Disease-Like Amyloid-β Pathology and Neuroinflammation in the Rat Hippocampus." in: Scientific reports, Vol. 5, pp. 12943, (2016) (PubMed).

    Liao, Jiang, Wang, Zhao, Chen, Li, Wang, Jie, Zhou, Zhang, Chen, Hu: "Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration." in: Scientific reports, Vol. 5, pp. 15356, (2016) (PubMed).

    Zhu, Li, Luo, Wang, Li, Xie, Gao, Song, Su, Liang et al.: "Reversion of malignant phenotypes of human glioblastoma cells by β-elemene through β-catenin-mediated regulation of stemness-, differentiation- and epithelial-to-mesenchymal transition-related ..." in: Journal of translational medicine, Vol. 13, pp. 356, (2016) (PubMed).

    Hu, Zhang, Tian, Xun, Wang, Lv: "Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro." in: Molecular medicine reports, Vol. 13, Issue 1, pp. 49-58, (2016) (PubMed).

    Xiao, Zhang, Zhang, Wang, Chen, Chen, Lv, Shi, Dong: "Re-infection of the prion from the scrapie‑infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c." in: International journal of molecular medicine, Vol. 37, Issue 3, pp. 716-26, (2016) (PubMed).

    Yang, Li, Li, Feng, Liu, Han, Zhang, Qin, Zhang, Nie, Jin: "Effect of Corilagin on the Proliferation and NF-κB in U251 Glioblastoma Cells and U251 Glioblastoma Stem-Like Cells." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2016, pp. 1418309, (2016) (PubMed).

    show more references

  • 抗原

    GFAP (Glial Fibrillary Acidic Protein (GFAP))

    别名

    GFAP

    背景

    Synonyms: Glial fibrillary acidic protein;GFAP;GFAP;

    Tissue Specificity: Expressed in cells lacking fibronectin. .

    Background: Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans. It is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes, and ependymal cells. It is mapped to 17q21.31. GFAP is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cells. This gene has been shown to play a role in mitosis by adjusting the filament network present in the cell. GFAP is necessary for many critical roles in the CNS. What’s more, GFAP also plays a role in astrocyte-neuron interactions as well as cell-cell communication.

    Sequence Similarities: Belongs to the intermediate filament family.

    分子量

    50 kDa

    基因ID

    2670

    UniProt

    P14136
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