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CTNNA1 抗体 (AA 143-292)

Name: CTNNA1 抗体 (AA 143-292)
SKU: ABIN3043818
Availability: OutOfStock

CTNNA1 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

Western Blotting (WB) image for anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 143-292) antibody (ABIN3043818) (CTNNA1 抗体 (AA 143-292))

Anti-CTNNA1 Picoband antibody, IHC(P): Rat Intestine Tissue (CTNNA1 抗体 (AA 143-292))

IHC

Anti-CTNNA1 Picoband antibody, IHC(P): Human Mammary Tissue (CTNNA1 抗体 (AA 143-292))

IHC

Anti-CTNNA1 Picoband antibody, IHC(P): Mouse Intestine Tissue (CTNNA1 抗体 (AA 143-292))

IHC

Anti-CTNNA1 Picoband antibody, All lanes: Anti CTNNA1 at 0. (CTNNA1 抗体 (AA 143-292))

5 images

(2 references)

产品编号 ABIN3043818

发货至: 中国

Datasheet as PDF

抗原 See all CTNNA1 抗体

CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
抗原表位
13

4

4

4

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 143-292
适用
71

40

26

4

4

3

2

2

2

2

2
人, 小鼠, 大鼠
宿主
53

19

1
兔
Compatible Secondaries
克隆类型
42

30

1
多克隆
标记
46

5

2

2

2

2

2

2

2

2

1

1

1

1

1

1
This CTNNA1 antibody is un-conjugated
应用范围
45

30

23

21

17

16

10

7

2

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

原理

Anti-alpha 1 Catenin/CTNNA1 Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-alpha 1 Catenin/CTNNA1 Antibody Picoband® (ABIN3043818). Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292). Human CTNNA1 shares 98% amino acid (aa) sequence identity with mouse CTNNA1.

亚型

IgG

Top Product

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anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (C-Term) antibody
CTNNA1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 637-906) antibody
CTNNA1 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated

anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) antibody
CTNNA1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (Internal Region) antibody
Verified CTNNA1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 371-574) antibody
CTNNA1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 8B6C1 unconjugated

anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 2-228) antibody
CTNNA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 1-288) antibody
CTNNA1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (AA 152-250) antibody
CTNNA1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4G6 unconjugated

anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (pSer641) antibody
CTNNA1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) antibody
CTNNA1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human1. Vasioukhin, V., Bauer, C., Degenstein, L., Wise, B., Fuchs, E. Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 104: 605-617, 2001. 2. Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (November 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proc Natl Acad Sci U S A 88 (20): 9156-60. 3. "Entrez Gene: CTNNA1 catenin (cadherin-associated protein), alpha 1, 102 kDa"

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Ren, Qiu, Lü, Ru, Li, Xiang, Yu, Zhang: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).

Lin, Wu, Li, Wu, Zheng: "Prognostic and clinicopathological features of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D1 expression in human esophageal squamous cell carcinoma." in: World journal of gastroenterology, Vol. 10, Issue 22, pp. 3235-9, (2005) (PubMed).
抗原

CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

别名

CTNNA1 (CTNNA1 产品)

背景

Synonyms: Catenin alpha-1,Alpha E-catenin,Cadherin-associated protein,Renal carcinoma antigen NY-REN-13,CTNNA1,
Tissue Specificity: Expressed ubiquitously in normal tissues.
Background: CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.
Sequence Similarities: Belongs to the vinculin/alpha-catenin family.

分子量

100 kDa

基因ID

1495

UniProt

P35221

途径

Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location