COMT 抗体 (AA 52-271)
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- 抗原 See all COMT 抗体
- COMT (Catechol-O-Methyltransferase (COMT))
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抗原表位
- AA 52-271
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This COMT antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
- 原理
- Anti-COMT Antibody Picoband®
- 交叉反应 （详细）
- No cross-reactivity with other proteins
- 产品特性
- Anti-COMT Antibody Picoband® (ABIN3043815). Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human COMT recombinant protein (Position: G52-P271). Human COMT shares 81.9% and 81% amino acid (aa) sequence identity with mouse and rat COMT, respectively.
- 亚型
- IgG
- Top Product
- Discover our top product COMT Primary Antibody
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anti-Catechol-O-Methyltransferase (COMT) (Internal Region) antibody
Verified COMT 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Catechol-O-Methyltransferase (COMT) (N-Term) antibodyVerified COMT 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Catechol-O-Methyltransferase (COMT) antibodyKO Validated COMT 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Catechol-O-Methyltransferase (COMT) (AA 1-182) antibodyCOMT 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G4-1A1 unconjugated
anti-Catechol-O-Methyltransferase (COMT) (AA 52-271) antibodyCOMT 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Catechol-O-Methyltransferase (COMT) (Internal Region) antibodyCOMT 适用: 人, 小鼠, 大鼠, 猴, Cow, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Catechol-O-Methyltransferase (COMT) (C-Term) antibodyCOMT 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Catechol-O-Methyltransferase (COMT) (AA 1-221) antibodyCOMT 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Catechol-O-Methyltransferase (COMT) (AA 1-221) antibodyCOMT 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Catechol-O-Methyltransferase (COMT) antibodyCOMT 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 8E1 unconjugated Recombinant Antibody
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- 应用备注
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Immunocytochemistry , 0.5-1 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
Western blot, 0.1-0.5 μg/mL
1. Baker, K., Baldeweg, T., Sivagnanasundaram, S., Scambler, P., Skuse, D. COMT val108/158met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome. Biol. Psychiat. 58: 23-31, 2005. 2. Lee, S.-G., Joo, Y., Kim, B., Chung, S., Kim, H.-L., Lee, I., Choi, B., Kim, C., Song, K.Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. Hum. Genet. 116: 319-328, 2005. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- 抗原
- COMT (Catechol-O-Methyltransferase (COMT))
- 别名
- COMT (COMT 产品)
- 背景
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Synonyms: Catechol O-methyltransferase,2.1.1.6,COMT,
Tissue Specificity: Brain, liver, placenta, lymphocytes and erythrocytes.
Background: Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini.
Sequence Similarities: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family.
- 分子量
- 24 kDa, 28 kDa
- 基因ID
- 1312
- UniProt
- P21964
- 途径
- Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome
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