CLOCK 抗体 (N-Term)
Quick Overview for CLOCK 抗体 (N-Term) (ABIN3043813)
抗原
See all CLOCK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 75-109, N-Term
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原理
- Anti-KAT13D/CLOCK Antibody Picoband®
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序列
- QKSIDFLRKH KEITAQSDAS EIRQDWKPTF LSNEE
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-KAT13D/CLOCK Picoband® Antibody (ABIN3043813). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human KAT13D/CLOCK, different from the related mouse sequence by one amino acid, and identical to the related rat sequence.
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亚型
- IgG
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anti-Clock Homolog (Mouse) (CLOCK) (Internal Region) antibody
CLOCK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Clock Homolog (Mouse) (CLOCK) (AA 577-846) antibodyCLOCK 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Clock Homolog (Mouse) (CLOCK) (AA 577-846) antibodyCLOCK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Clock Homolog (Mouse) (CLOCK) antibodyCLOCK 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 8F7 unconjugated
anti-Clock Homolog (Mouse) (CLOCK) (AA 497-596) antibodyCLOCK 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Clock Homolog (Mouse) (CLOCK) (C-Term) antibodyCLOCK 适用: 人, 小鼠 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Clock Homolog (Mouse) (CLOCK) antibodyCLOCK 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 8F7 unconjugated
anti-Clock Homolog (Mouse) (CLOCK) (AA 34-379) antibodyCLOCK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Clock Homolog (Mouse) (CLOCK) (AA 458-472) antibodyVerified CLOCK 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Monkey, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
1. Dunlap JC (Jan 1999). "Molecular bases for circadian clocks". Cell 96 (2): 271-90. 2. King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL, Turek FW, Takahashi JS (May 1997). "Positional cloning of the mouse circadian clock gene". Cell 89 (4): 641-653. 3. Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS (Apr 1994). "Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior". Science 264 (5159): 719-25. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CLOCK (Clock Homolog (Mouse) (CLOCK))
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别名
- CLOCK
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背景
- Clock (Circadian Locomotor Output Cycles Kaput) is also known as KAT13D. The protein encoded by this gene plays a central role in the regulation of circadian rhythms. This protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. And the encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.
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分子量
- 110 kDa
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基因ID
- 9575
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UniProt
- O15516
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途径
- Regulation of Lipid Metabolism by PPARalpha, Photoperiodism
抗原
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