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Aquaporin 4 抗体 (C-Term)

AQP4 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

Anti- Aquaporin 4 Picoband antibody, Western blotting All lanes: Anti Aquaporin 4 at 0. (Aquaporin 4 抗体 (C-Term))

Anti- Aquaporin 4 Picoband antibody, IHC(P) IHC(P): Rat Brain Tissue (Aquaporin 4 抗体 (C-Term))

Anti- Aquaporin 4 Picoband antibody, IHC(P) IHC(P): Human Glioma Tissue (Aquaporin 4 抗体 (C-Term))

Anti- Aquaporin 4 Picoband antibody, IHC(F) IHC(F): Rat Brain Tissue (Aquaporin 4 抗体 (C-Term))

Anti- Aquaporin 4 Picoband antibody, IHC(F) IHC(F): Mouse Brain Tissue (Aquaporin 4 抗体 (C-Term))

Anti- Aquaporin 4 Picoband antibody, IHC(P): Rat Brain Tissue (Aquaporin 4 抗体 (C-Term))

Anti- Aquaporin 4 Picoband antibody, IHC(P) IHC(P): Mouse Brain Tissue (Aquaporin 4 抗体 (C-Term))

7 images

(5 references)

产品编号 ABIN3043789

发货至: 中国

Datasheet as PDF

抗原 See all Aquaporin 4 (AQP4) 抗体

Aquaporin 4 (AQP4)
抗原表位
15

15

6

4

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 295-323, C-Term
适用
66

59

51

4

4

1

1

1
人, 小鼠, 大鼠
宿主
71

17

1
兔
Compatible Secondaries
克隆类型
67

21

1
多克隆
标记
45

7

5

4

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This Aquaporin 4 antibody is un-conjugated
应用范围
59

39

24

23

19

18

15

12

12

11

4

4

3

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

原理

Anti-Aquaporin 4/AQP4 Antibody Picoband®

序列

KPGVVHVIDV DRGEEKKGKD QSGEVLSSV

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Aquaporin 4/AQP4 Antibody Picoband® (ABIN3043789). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 4, different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids.

亚型

IgG

Top Product

Discover our top product AQP4 Primary Antibody
anti-Aquaporin 4 (AQP4) (AA 271-323) antibody
AQP4 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Aquaporin 4 (AQP4) (AA 178-317) antibody
AQP4 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Aquaporin 4 (AQP4) (AA 253-323) antibody
AQP4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Aquaporin 4 (AQP4) antibody
Microarray verified AQP4 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB430199 unconjugated

anti-Aquaporin 4 (AQP4) antibody
Microarray verified AQP4 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB287702 unconjugated

anti-Aquaporin 4 (AQP4) antibody
AQP4 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated

anti-Aquaporin 4 (AQP4) (AA 258-27) antibody
AQP4 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Aquaporin 4 (AQP4) (AA 178-317) antibody
AQP4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Aquaporin 4 (AQP4) (AA 177-304) antibody
AQP4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Aquaporin 4 (AQP4) (AA 179-314) antibody
AQP4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Mouse, Rat
1. Amiry-Moghaddam, M., Otsuka, T., Hurn, P. D., Traystman, R. J., Haug, F.-M., Froehner, S. C., Adams, M. E., Neely, J. D., Agre, P., Ottersen, O. P., Bhardwaj, A. : An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers biional water flow between blood and brain. Proc. Nat. Acad. Sci. 100: 2106-2111, 2003. 2. Agre P, Nielsen S (1996). "The aquaporin family of water channels in kidney". Nephrologie 17 (7): 409-15. 3. Lennon, V. A., Kryzer, T. J., Pittock, S. J., Verkman, A. S., Hinson, S. R. : IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J. Exp. Med. 202: 473-477, 2005. 4. Lu, M., Lee, M. D., Smith, B. L., Jung, J. S., Agre, P., Verdijk, M. A. J., Merkx, G., Rijss, J. P. L., Deen, P. M. T. : The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain. Proc. Nat. Acad. Sci. 93: 10908-10912, 1996. 5. Nagelhus EA, Mathiisen TM, Ottersen OP (2004). "Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1". Neuroscience 129 (4): 905-13.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Han, Huang, Liu, Sha, Hu, Liu: "Changes in the Expression of AQP4 and AQP9 in the Hippocampus Following Eclampsia-Like Seizure." in: International journal of molecular sciences, Vol. 19, Issue 1, (2018) (PubMed).

Anzabi, Ardalan, Iversen, Rafati, Hansen, Østergaard: "Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4." in: Frontiers in cellular neuroscience, Vol. 12, pp. 19, (2018) (PubMed).

Wang, Bu, Zhang, Chen, Zhang, Bao: "Expression pattern of aquaporins in patients with primary nephrotic syndrome with edema." in: Molecular medicine reports, Vol. 12, Issue 4, pp. 5625-32, (2016) (PubMed).

Zhang, Chen, Dang, Liu, Ito, Sun: "Neuroprotective effects of total steroid saponins on cerebral ischemia injuries in an animal model of focal ischemia/reperfusion." in: Planta medica, Vol. 80, Issue 8-9, pp. 637-44, (2015) (PubMed).

Chen, Huang, Ruan, He, Li: "Ulinastatin attenuates cerebral ischemia-reperfusion injury in rats." in: International journal of clinical and experimental medicine, Vol. 7, Issue 5, pp. 1483-9, (2014) (PubMed).
抗原

Aquaporin 4 (AQP4)

别名

AQP4 (AQP4 产品)

背景

Synonyms: Aquaporin-4,AQP-4,Mercurial-insensitive water channel,MIWC,WCH4,AQP4,
Tissue Specificity: Brain - muscle >> heart, kidney, lung, and trachea.
Background: Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. The gene of AQP4 is mapped to 18q11.2-q12.1. Similar to other aquaporins, the AQP4 gene is composed of 4 exons encoding 127, 55, 27, and 92 amino acids separated by introns of 0.8, 0.3, and 5.2 kb. Unlike other aquaporins, an alternative coding initiation sequence (designated exon 0) was located 2.7 kb upstream of exon 1. When spliced together, M1 and the subsequent 10 amino acids are encoded by exon 0, the next 11 amino acids and M23 are encoded by exon 1. AQP4 is expressed in astrocytes and is upregulated by insult to the central nervous system. And AQP4 is the predominant water channel in the brain and has an important role in brain water homeostasis. It is abundant in mammalian brain and is concentrated in astrocytic foot processes at the blood-brain barrier.
Sequence Similarities: Belongs to the MIP/aquaporin (TC 1.A.8) family.

分子量

37 kDa

基因ID

361

UniProt

P55087

途径

Sensory Perception of Sound

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