HRH3 抗体 (C-Term)
Quick Overview for HRH3 抗体 (C-Term) (ABIN3043704)
抗原
See all HRH3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 428-445, C-Term
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原理
- Anti-Histamine H3 receptor HRH3 Antibody Picoband®
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序列
- CPQKLKIQPH SSLEHCWK
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Histamine H3 receptor HRH3 Antibody (ABIN3043704). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human HRH3, different from the related rat sequence by three amino acids.
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亚型
- IgG
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anti-Histamine Receptor H3 (HRH3) (Cytoplasmic Domain) antibody
HRH3 适用: 人, 猴 IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 236-332) antibodyHRH3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (C-Term) antibodyHRH3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 250-350) antibodyHRH3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) antibodyHRH3 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 121-220) antibodyHRH3 适用: 人, 大鼠 WB, IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (Cytoplasmic Domain) antibodyHRH3 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (Cytoplasmic Domain) antibodyHRH3 适用: 人, 大鼠, 小鼠, Cow, 马, 豚鼠, Hamster, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (Internal Region) antibodyVerified HRH3 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Histamine Receptor H3 (HRH3) (AA 257-359) antibodyHRH3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D7 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Hill, S. J., Ganellin, C. R., Timmerman, H., Schwartz, J. C., Shankley, N. P., Young, J. M., Schunack, W., Levi, R., Haas, H. L. : International Union of Pharmacology. XIII. Classification of histamine receptors. Pharm. Rev. 49: 253-278, 1997. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- HRH3 (Histamine Receptor H3 (HRH3))
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别名
- HRH3
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背景
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Synonyms: Histamine H3 receptor,H3R,HH3R,G-protein coupled receptor 97,HRH3,GPCR97,
Tissue Specificity: Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
Background: The histamine receptor H3 (HRH3) is a presynaptic autoreceptor on histamine neurons in the brain and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. The deduced 445-amino acid HRH3 protein contains 7 predicted transmembrane domains. And it shares 22 % and 21.4 % amino acid sequence homology with the H1 (HRH1) and H2 (HRH2) receptors, respectively. The expression of recombinant HRH3 in a variety of cell lines conferred an ability to inhibit adenylate cyclase in response to histamine, but not to acetylcholine or any other biogenic amine. Additionally, HRH3 was most notably observed throughout the thalamus, the ventromedial hypothalamus, and the caudate nucleus. Strong expression was also seen in layers II, V, and VIb of the cerebral cortex, in the pyramidal layers of the hippocampus, and in olfactory tubercle.
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分子量
- 49 kDa
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UniProt
- Q9Y5N1
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途径
- cAMP Metabolic Process, Feeding Behaviour
抗原
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